Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

Encequidar

🥰Excellent
Catalog No. T8426Cas No. 849675-66-7
Alias HM30181A, HM30181

Encequidar (HM30181A) is a potent and selective P-glycoprotein inhibitor.

Encequidar

Encequidar

🥰Excellent
Purity: 99.93%
Catalog No. T8426Alias HM30181A, HM30181Cas No. 849675-66-7
Encequidar (HM30181A) is a potent and selective P-glycoprotein inhibitor.
Pack SizePriceAvailabilityQuantity
1 mg$41In Stock
2 mg$59In Stock
5 mg$97In Stock
10 mg$147In Stock
25 mg$259In Stock
50 mg$401In Stock
100 mg$587In Stock
1 mL x 10 mM (in DMSO)$136In Stock
Bulk & Custom
Add to Cart
Questions
View More

Related Compound Libraries of "Encequidar"

Select Batch
Purity:99.93%
Contact us for more batch information
Resource Download
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
Encequidar (HM30181A) is a potent and selective P-glycoprotein inhibitor.
In vivo
HM30181 to inhibit Pgp at the murine BBB.?HM30181 was shown to be approximately equipotent with the reference Pgp inhibitor tariquidar in inhibiting rhodamine 123 efflux from CCRF-CEM T cells (IC(50), tariquidar: 8.2 2.0 nM, HM30181: 13.1 2.3 nM).?PET scans with the Pgp substrate (R)-[(11)C]verapamil in FVB wild-type mice pretreated i.v. with HM30181 (10 or 21 mg/kg) failed to show significant increases in (R)-[(11)C]verapamil brain uptake compared with vehicle treated animals.?PET scans with [(11)C]HM30181 showed low and not significantly different brain uptake of [(11)C]HM30181 in wild-type, Mdr1a/b((-/-)) and Bcrp1((-/-)) mice and significantly, i.e. 4.7-fold (P<0.01), higher brain uptake, relative to wild-type animals, in Mdr1a/b((-/-))Bcrp1((-/-)) mice[1].
AliasHM30181A, HM30181
Chemical Properties
Molecular Weight688.73
FormulaC38H36N6O7
Cas No.849675-66-7
SmilesCOc1cc2CCN(CCc3ccc(cc3)-n3nnc(n3)-c3cc(OC)c(OC)cc3NC(=O)c3cc(=O)c4ccccc4o3)Cc2cc1OC
Relative Density.1.35 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 6.9 mg/mL (10.02 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.4519 mL7.2597 mL14.5195 mL72.5974 mL
5 mM0.2904 mL1.4519 mL2.9039 mL14.5195 mL
10 mM0.1452 mL0.7260 mL1.4519 mL7.2597 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy Encequidar | purchase Encequidar | Encequidar cost | order Encequidar | Encequidar chemical structure | Encequidar in vivo | Encequidar formula | Encequidar molecular weight