Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ensartinib hydrochloride (X-396 dihydrochloride) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of known crizotinib-resistant ALK mutations. It potently inhibits both wild-type ALK and ALK variants (C1156Y, F1174, G1202R, L1196M, S1206R, and T1151 mutants) with in vitro IC50s of <4 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 60.00 | |
2 mg | In stock | $ 85.00 | |
5 mg | In stock | $ 147.00 | |
10 mg | In stock | $ 239.00 | |
25 mg | In stock | $ 488.00 | |
50 mg | In stock | $ 712.00 | |
100 mg | In stock | $ 987.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 198.00 |
Description | Ensartinib hydrochloride (X-396 dihydrochloride) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of known crizotinib-resistant ALK mutations. It potently inhibits both wild-type ALK and ALK variants (C1156Y, F1174, G1202R, L1196M, S1206R, and T1151 mutants) with in vitro IC50s of <4 nM. |
Targets&IC50 | TPM3-TRKA:<1 nM, TrkC:<1 nM, ALK:<4 nM, ALK (variants):<4 nM, GOPC-ROS1:<1 nM |
In vitro | Ensartinib potently inhibits both wild-type ALK and all evaluated ALK variants (C1156Y, F1174, G1202R, L1196M, S1206R, and T1151 mutants) with in vitro IC50s of <4 nM. Besides ALK, ensartinib also potently inhibits GOPC-ROS1, TPM3-TRKA, and TRKC with an IC50 of <1 nM, and inhibits EphA1, EphA2, EphB1 and c-MET with an IC50 of 1-10 nM[1]. |
Synonyms | Ensartinib dihydrochloride, X-396 dihydrochloride |
Molecular Weight | 634.36 |
Formula | C26H29Cl4FN6O3 |
CAS No. | 2137030-98-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 33mg/ml (52.02 mM)
You can also refer to dose conversion for different animals. More
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Ensartinib hydrochloride 2137030-98-7 Angiogenesis Others Tyrosine Kinase/Adaptors Trk receptor c-Met/HGFR ALK X 396 X396 Cluster of differentiation 246 Ensartinib Ensartinib dihydrochloride Inhibitor CD246 X-396 Ensartinib Hydrochloride Anaplastic lymphoma kinase (ALK) Anaplastic lymphoma kinase X-396 dihydrochloride ALK tyrosine kinase receptor X-396 Dihydrochloride X396 Dihydrochloride inhibit X 396 Dihydrochloride Ensartinib Dihydrochloride inhibitor