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Ensartinib hydrochloride
Catalog No. T22324Cas No. 2137030-98-7
Alias X-396 dihydrochloride, Ensartinib dihydrochloride
Ensartinib hydrochloride (X-396 dihydrochloride) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of known crizotinib-resistant ALK mutations. It potently inhibits both wild-type ALK and ALK variants (C1156Y, F1174, G1202R, L1196M, S1206R, and T1151 mutants) with in vitro IC50s of <4 nM.
Ensartinib hydrochloride
Catalog No. T22324Alias X-396 dihydrochloride, Ensartinib dihydrochlorideCas No. 2137030-98-7
Ensartinib hydrochloride (X-396 dihydrochloride) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of known crizotinib-resistant ALK mutations. It potently inhibits both wild-type ALK and ALK variants (C1156Y, F1174, G1202R, L1196M, S1206R, and T1151 mutants) with in vitro IC50s of <4 nM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $60 | In Stock | |
| 2 mg | $85 | In Stock | |
| 5 mg | $147 | In Stock | |
| 10 mg | $239 | In Stock | |
| 25 mg | $488 | In Stock | |
| 50 mg | $712 | In Stock | |
| 100 mg | $987 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $198 | In Stock |
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Purity:98.73%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Ensartinib hydrochloride (X-396 dihydrochloride) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of known crizotinib-resistant ALK mutations. It potently inhibits both wild-type ALK and ALK variants (C1156Y, F1174, G1202R, L1196M, S1206R, and T1151 mutants) with in vitro IC50s of <4 nM. |
| Targets&IC50 | GOPC-ROS1:<1 nM, ALK (variants):<4 nM, ALK:<4 nM, TrkC:<1 nM, TPM3-TRKA:<1 nM |
| In vitro | Ensartinib potently inhibits both wild-type ALK and all evaluated ALK variants (C1156Y, F1174, G1202R, L1196M, S1206R, and T1151 mutants) with in vitro IC50s of <4 nM. Besides ALK, ensartinib also potently inhibits GOPC-ROS1, TPM3-TRKA, and TRKC with an IC50 of <1 nM, and inhibits EphA1, EphA2, EphB1 and c-MET with an IC50 of 1-10 nM[1]. |
| Alias | X-396 dihydrochloride, Ensartinib dihydrochloride |
| Molecular Weight | 634.36 |
| Formula | C26H29Cl4FN6O3 |
| Cas No. | 2137030-98-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 33 mg/mL (52.02 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords
X 396X396Cluster of differentiation 246EnsartinibInhibitorCD246X-396Ensartinib HydrochlorideAnaplastic lymphoma kinase (ALK)Anaplastic lymphoma kinasec-Met/HGFRALK tyrosine kinase receptorEnsartinib hydrochlorideX-396 DihydrochlorideX396 DihydrochlorideinhibitX 396 DihydrochlorideEnsartinib Dihydrochloride
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