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FG 7142

Catalog No. T11277 CAS 78538-74-6

Synonyms: ZK 39106, LSU-65

FG 7142 (LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex. FG 7142 , a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM).

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FG 7142, CAS 78538-74-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 33.00
2 mg	In stock	$ 47.00
5 mg	In stock	$ 97.00
10 mg	In stock	$ 163.00
25 mg	In stock	$ 266.00
50 mg	In stock	$ 395.00
100 mg	In stock	$ 588.00
500 mg	In stock	$ 1,260.00
1 mL * 10 mM (in DMSO)	In stock	$ 59.00

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Purity: 98.81%

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Description	FG 7142 (LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex. FG 7142 , a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM).
Targets&IC50	GABAA receptor:ki： 91 nM
In vitro	FG-7142 has a high efficacy in modulating GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50 = 137 nM) as compared to the other α subunits.FG-7142 has affinity for those expressing the α subunit, the Ki values are 91 nM; 330 nM; 492 nM and 2.150 μM for α1, α2,α3 and α5 subunits, respectively.
In vivo	FG-7142, administered via intraperitoneal injection at doses of 15 mg/kg, enhances tyrosine hydroxylase activity and dopamine turnover specifically in the medial prefrontal cortex and ventral tegmentum, without impacting mesolimbic or nigrostriatal regions. At doses between 15-30 mg/kg, it stimulates mesolimbocortical dopaminergic projections, resulting in elevated dopamine levels in the prefrontal cortex and nucleus accumbens in rats.

Synonyms	ZK 39106, LSU-65
Molecular Weight	225.25
Formula	C13H11N3O
CAS No.	78538-74-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (133.19 mM)

References and Literature

1. Cottone P, et al. FG 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: evidence that benzodiazepine inverse agonists reduce food palatability.Neuropsychopharmacology. 2007 May;32(5):1069-81. Epub 2006 Nov 1.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Ion Channel Inhibitor Library Anti-Cancer Compound Library Neurotransmitter Receptor Compound Library Anti-Alzheimer's Disease Compound Library Bioactive Compounds Library Max Anti-Parkinson's Disease Compound Library Antidepressant Compound Library Bioactive Compound Library Neuronal Signaling Compound Library

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Keywords

FG 7142 78538-74-6 Membrane transporter/Ion channel Neuroscience GABA Receptor nucleus accumben inverse agonist LSU 65 ZK 39106 dopaminergic LSU-65 GABAA receptor inhibit Gamma-aminobutyric acid Receptor FG-7142 ZK39106 LSU65 ZK-39106 FG7142 tyrosine hydroxylase γ-Aminobutyric acid Receptor Inhibitor inhibitor

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