Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Fevipiprant is a selective, potent, reversible competitive CRTh2 antagonist.
Description | Fevipiprant is a selective, potent, reversible competitive CRTh2 antagonist. |
Targets&IC50 | CRTH2:0.44 nM |
In vitro | CRTh2-mediated shape change in eosinophils was used to profile QAW039 in whole blood and represents a physiologically relevant environment. The comparable IC50 values for QAW039 in the whole blood and isolated shape-change assays are consistent with its lower plasma-protein binding and its relatively slow dissociation kinetics that drive its increased potency .QAW039 is highly potent in whole-blood systems, with the IC50 value obtained consistent with the affinity values calculated from radioligand experiments. In a further disease-relevant cellular context, the potency of QAW039 in the isolated Th2 cell cytokine inhibition assay is consistent with its CRTh2 receptor affinity, and, as with eosinophil assay readouts, this represents an improved potency compared with QAV680.[ |
Synonyms | IL-4, inhibit, Inhibitor, bronchial asthma, Fevipiprant, QAW039, Th2 cells, QAW 039, abdominal aortic aneurysm, Prostaglandin Receptor, QAW-039, orally active, NVP-QAW039 |
Molecular Weight | 426.41 |
Formula | C19H17F3N2O4S |
CAS No. | 872365-14-5 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 32 mg/mL
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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