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Fevipiprant

Catalog No. T3965 CAS 872365-14-5

Synonyms: QAW039, NVP-QAW039

Fevipiprant is a selective, potent, reversible competitive CRTh2 antagonist.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Fevipiprant, CAS 872365-14-5

Pack Size	Availability	Price/USD
5 mg	In stock	$ 47.00
10 mg	In stock	$ 72.00
25 mg	In stock	$ 147.00
50 mg	In stock	$ 228.00
100 mg	In stock	$ 372.00
200 mg	In stock	$ 549.00
1 mL * 10 mM (in DMSO)	In stock	$ 52.00

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Purity: 99.32%

Purity: 98%

Biological Description

Chemical Properties

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Description	Fevipiprant is a selective, potent, reversible competitive CRTh2 antagonist.
Targets&IC50	CRTH2:0.44 nM
In vitro	CRTh2-mediated shape change in eosinophils was used to profile QAW039 in whole blood and represents a physiologically relevant environment. The comparable IC50 values for QAW039 in the whole blood and isolated shape-change assays are consistent with its lower plasma-protein binding and its relatively slow dissociation kinetics that drive its increased potency .QAW039 is highly potent in whole-blood systems, with the IC50 value obtained consistent with the affinity values calculated from radioligand experiments. In a further disease-relevant cellular context, the potency of QAW039 in the isolated Th2 cell cytokine inhibition assay is consistent with its CRTh2 receptor affinity, and, as with eosinophil assay readouts, this represents an improved potency compared with QAV680.[

Synonyms	QAW039, NVP-QAW039
Molecular Weight	426.41
Formula	C19H17F3N2O4S
CAS No.	872365-14-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 32 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Sykes DA, et al. Fevipiprant (QAW039), a Slowly Dissociating CRTh2 Antagonist with the Potential for Improved Clinical Efficacy. Mol Pharmacol. 2016 May;89(5):593-605. 2. Erpenbeck VJ, rt al. Pharmacokinetics, Safety, and Tolerability of Fevipiprant (QAW039), a Novel CRTh2 Receptor Antagonist: Results From 2 Randomized, Phase 1, Placebo-Controlled Studies in Healthy Volunteers. Clin Pharmacol Drug Dev. 2016 Jul;5(4):306-13.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Target-Focused Phenotypic Screening Library Anti-Obesity Compound Library Bioactive Compound Library Inhibitor Library ReFRAME Related Library Bioactive Compounds Library Max Clinical Compound Library GPCR Compound Library Immunology/Inflammation Compound Library

Related Products

Related compounds with same targets

Fezagepras sodium CRTh2 antagonist 2 FL104 BTB09089 GPR35 agonist 2 GLPG1205 BMS-903452 TUG-770

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Fevipiprant 872365-14-5 Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation GPR Prostaglandin Receptor IL-4 inhibit Inhibitor bronchial asthma QAW039 Th2 cells QAW 039 abdominal aortic aneurysm QAW-039 orally active NVP-QAW039 inhibitor

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