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Fluoxetine

Catalog No. T0450   CAS 54910-89-3
Synonyms: Inhibitor, SERT, Fluoxetine, inhibit, 5-HTT, SLC6A4, LY-110140, Autophagy, Serotonin Transporter, LY 110140, LY110140

Fluoxetine is the first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.

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Fluoxetine, CAS 54910-89-3
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Purity: 98%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Fluoxetine is the first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
In vitro Fluoxetine blocks the downregulation of cell proliferation resulting from inescapable shock (IS) of hippocampal cell[1]. Fluoxetine increases the number of newborn cells in the dentate gyrus of the hippocampus of adult rats which also increases the number of proliferating cells in the prelimbic cortex[2]. Fluoxetine accelerates the maturation of immature neurons. Fluoxetine enhances neurogenesis-dependent long-term potentiation (LTP) in the dentate gyrus[3]. Fluoxetine, but not citalopram, fluvoxamine, paroxetine and sertraline, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Fluoxetine produces robust and sustained increases in extracellular concentrations of norepinephrine and dopamine after acute systemic administration[4].
In vivo Fluoxetine treatment also reverses the escape latency deficit observed in animals exposed to inescapable shock in adult male Sprague-Dawley rats[1]. Fluoxetine (5 mg/kg) alone increases cell proliferation in the dentate gyrus. Compared to the controls, Coadministration (fluoxetine 5 mg/kg + olanzapine) also significantly increases the number of BrdU-positive cells [2]. Fluoxetine combined with Olanzapine produces robust, sustained increases of extracellular levels of dopamine ([DA](ex)) and norepinephrine ([NE](ex)) up to 361% and 272% of the baseline, respectively, which are significantly greater than either drug alone[5].
Synonyms Inhibitor, SERT, Fluoxetine, inhibit, 5-HTT, SLC6A4, LY-110140, Autophagy, Serotonin Transporter, LY 110140, LY110140
Molecular Weight 309.332
Formula C17H18F3NO
CAS No. 54910-89-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Jiang B, Wang H, Wang J L, et al. Hippocampal Salt-Inducible Kinase 2 Plays a Role in Depression Via the CREB-Regulated Transcription Coactivator 1-Cyclic AMP Response Element Binding-Brain-Derived Neurotrophic Factor Pathway. Biological Psychiatry. 2019, 85(8): 650-666 1. Malberg JE, et al. Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment. Neuropsychopharmacology. 2003 Sep;28(9):1562-71. 2. Kodama M, et al. Chronic olanzapine or fluoxetine administration increases cell proliferation in hippocampus and prefrontal cortex of adult rat. Biol Psychiatry. 2004 Oct 15;56(8):570-80. 2. Persaud R, Li S C, Chao J D, et al. Clionamines stimulate autophagy, inhibit Mycobacterium tuberculosis survival in macrophages, and target Pik1. Cell Chemical Biology. 2021 3. Wu X, Lv J, Zhang S, et al. ML365 inhibits TWIK2 channel to block ATP-induced NLRP3 inflammasome. Acta Pharmacologica Sinica. 2021: 1-9. 3. Wang JW, et al. Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells. J Neurosci. 2008 Feb 6;28(6):1374-84. 4. Bymaster FP, et al. Fluoxetine, but not other selective serotonin uptake inhibitors, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Psychopharmacology (Berl). 2002 Apr;160(4):353-61. 4. Lv J, Liang Y, Zhang S, et al. DCPIB, an inhibitor of volume-regulated anion channels, distinctly modulates K2P channels. ACS Chemical Neuroscience. 2019, 10(6): 2786-2793 5. Zhang W, et al. Synergistic effects of olanzapine and other antipsychotic agents in combination with fluoxetine on norepinephrine and dopamine release in rat prefrontal cortex. Neuropsychopharmacology. 2000 Sep;23(3):250-62. 5. Liu Y, Tang W, Ji C, et al. The selective SIK2 inhibitor ARN-3236 produces strong antidepressant-like efficacy in mice via the hippocampal CRTC1-CREB-BDNF pathway. Frontiers in pharmacology. 2020, 11. 6. Liu L, Ji C H, Wang Y, et al. Antidepressant-like activity of L-701324 in mice: A behavioral and neurobiological characterization. Behavioural Brain Research. 2020: 113038. 6. Avitsur R1. Increased symptoms of illness following prenatal stress: Can it be prevented by fluoxetine Behav Brain Res. 2017 Jan 15;317:62-70. 7. Zhao J, Zhang Y, Liu Y, et al. Antidepressant-like effects of 1-methylnicotinamide in a chronic unpredictable mild stress model of depression[J]. Neuroscience Letters. 2020: 135535. 7. Zhao J, Zhang Y, Liu Y, et al. Antidepressant-like effects of 1-methylnicotinamide in a chronic unpredictable mild stress model of depression. Neuroscience Letters. 2021 Jan 18;742:135535. doi: 10.1016 8. Liu L, Ji C H, Wang Y, et al. Antidepressant-like activity of L-701324 in mice: A behavioral and neurobiological characterization[J]. Behavioural Brain Research. 2020: 113038. 8. Zhang H, Xu H, Tang Q, et al. The selective serotonin reuptake inhibitors enhance the cytotoxicity of sorafenib in hepatocellular carcinoma cells. Anti-Cancer Drugs. 2021, 32(8): 793-801. 9. Jinyan Lv, Yemei Liang, Shiqing Zhang, Qunsheng Lan, Ziwei Xu, Xiaoyan Wu, Lijun Kang, Jing Ren, Ying Cao, Ting Wu, Kai Li Lin, Ken Kin Lam Yung, Xiong Cao, Jianxin Pang, and Pingzheng Zhou . DCPIB, an inhibitor of volume-regulated anion channels, distinctly modulates K2P channels [J]. ACS Chemical Neuroscience. 2019 Apr 17. 10. Jiang Bo, et al. Hippocampal Salt-Inducible Kinase 2 Plays a Role in Depression Via the CREB-Regulated Transcription Coactivator 1-Cyclic AMP Response Element Binding-Brain-Derived Neurotrophic Factor Pathway [J]. Biological psychiatry. 2019 Apr 15;85(8):650-666.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Compound Library GPCR Compound Library Fluorochemical Library Anti-Cancer Approved Drug Library Anti-COVID-19 Compound Library Anti-Cancer Drug Library FDA-Approved & Pharmacopeia Drug Library Target-Focused Phenotypic Screening Library

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