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Giredestrant tartrate

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Purity:98.01%

ee:96.71%

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Giredestrant tartrate

Catalog No. T11236Cas No. 2407529-33-1

Giredestrant tartrate (Estrogen receptor antagonist 1) is a novel, orally active, selective and effective non-steroidal estrogen receptor antagonist. Giredestrant tartrate strongly binds to ER, resulting in the failure of ER to activate the transcription of targeted genes and promoting the degradation of ER protein. Giredestrant tartrate can be used to treat tumor diseases.

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Pack Size	Price	Availability
1 mg	$117	In Stock
5 mg	$268	In Stock
10 mg	$395	In Stock
25 mg	$592	In Stock
50 mg	$828	In Stock
100 mg	$1,130	In Stock
500 mg	Inquiry	In Stock

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Product Introduction

Bioactivity

Description	Giredestrant tartrate (Estrogen receptor antagonist 1) is a novel, orally active, selective and effective non-steroidal estrogen receptor antagonist. Giredestrant tartrate strongly binds to ER, resulting in the failure of ER to activate the transcription of targeted genes and promoting the degradation of ER protein. Giredestrant tartrate can be used to treat tumor diseases.
In vitro	Estrogen receptor antagonist 1 shows weak metabolism dependent inhibition of CYP2C9.Estrogen receptor antagonist 1 directly inhibits CYP3A4 with IC50 values of 6.5 µM (midazolam 1'-hydroxylation) and 26 µM (testosterone 6β-hydroxylation); IC50 for CYP2B6 and CYP2C8 inhibition were 13 µM and 21 µM, respectively.
Alias	Estrogen receptor antagonist 1

Chemical Properties

Molecular Weight	672.64
Formula	C31H37F5N4O7
Cas No.	2407529-33-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (81.77 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4867 mL	7.4334 mL	14.8668 mL	74.3340 mL
5 mM	0.2973 mL	1.4867 mL	2.9734 mL	14.8668 mL
10 mM	0.1487 mL	0.7433 mL	1.4867 mL	7.4334 mL
20 mM	0.0743 mL	0.3717 mL	0.7433 mL	3.7167 mL
50 mM	0.0297 mL	0.1487 mL	0.2973 mL	1.4867 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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