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Giredestrant tartrate (Estrogen receptor antagonist 1) is a novel, orally active, selective and effective non-steroidal estrogen receptor antagonist. Giredestrant tartrate strongly binds to ER, resulting in the failure of ER to activate the transcription of targeted genes and promoting the degradation of ER protein. Giredestrant tartrate can be used to treat tumor diseases.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $117 | In Stock | |
5 mg | $268 | In Stock | |
10 mg | $395 | In Stock | |
25 mg | $592 | In Stock | |
50 mg | $828 | In Stock | |
100 mg | $1,130 | In Stock | |
500 mg | Inquiry | In Stock |
Description | Giredestrant tartrate (Estrogen receptor antagonist 1) is a novel, orally active, selective and effective non-steroidal estrogen receptor antagonist. Giredestrant tartrate strongly binds to ER, resulting in the failure of ER to activate the transcription of targeted genes and promoting the degradation of ER protein. Giredestrant tartrate can be used to treat tumor diseases. |
In vitro | Estrogen receptor antagonist 1 shows weak metabolism dependent inhibition of CYP2C9.Estrogen receptor antagonist 1 directly inhibits CYP3A4 with IC50 values of 6.5 µM (midazolam 1'-hydroxylation) and 26 µM (testosterone 6β-hydroxylation); IC50 for CYP2B6 and CYP2C8 inhibition were 13 µM and 21 µM, respectively. |
Alias | Estrogen receptor antagonist 1 |
Molecular Weight | 672.64 |
Formula | C31H37F5N4O7 |
Cas No. | 2407529-33-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 55 mg/mL (81.77 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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