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Giredestrant tartrate

Catalog No. T11236Cas No. 2407529-33-1
Alias Estrogen receptor antagonist 1

Giredestrant tartrate (Estrogen receptor antagonist 1) is a novel, orally active, selective and effective non-steroidal estrogen receptor antagonist. Giredestrant tartrate strongly binds to ER, resulting in the failure of ER to activate the transcription of targeted genes and promoting the degradation of ER protein. Giredestrant tartrate can be used to treat tumor diseases.

Giredestrant tartrate

Giredestrant tartrate

Purity: 98.01%
Catalog No. T11236Alias Estrogen receptor antagonist 1Cas No. 2407529-33-1
Giredestrant tartrate (Estrogen receptor antagonist 1) is a novel, orally active, selective and effective non-steroidal estrogen receptor antagonist. Giredestrant tartrate strongly binds to ER, resulting in the failure of ER to activate the transcription of targeted genes and promoting the degradation of ER protein. Giredestrant tartrate can be used to treat tumor diseases.
Pack SizePriceAvailabilityQuantity
1 mg$117In Stock
5 mg$268In Stock
10 mg$395In Stock
25 mg$592In Stock
50 mg$828In Stock
100 mg$1,130In Stock
500 mgInquiryIn Stock
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Purity:98.01%
ee:96.71%
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Product Introduction

Bioactivity
Description
Giredestrant tartrate (Estrogen receptor antagonist 1) is a novel, orally active, selective and effective non-steroidal estrogen receptor antagonist. Giredestrant tartrate strongly binds to ER, resulting in the failure of ER to activate the transcription of targeted genes and promoting the degradation of ER protein. Giredestrant tartrate can be used to treat tumor diseases.
In vitro
Estrogen receptor antagonist 1 shows weak metabolism dependent inhibition of CYP2C9.Estrogen receptor antagonist 1  directly inhibits CYP3A4 with IC50 values of 6.5 µM (midazolam 1'-hydroxylation) and 26 µM (testosterone 6β-hydroxylation); IC50 for CYP2B6 and CYP2C8 inhibition were 13 µM and 21 µM, respectively. 
AliasEstrogen receptor antagonist 1
Chemical Properties
Molecular Weight672.64
FormulaC31H37F5N4O7
Cas No.2407529-33-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 55 mg/mL (81.77 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.4867 mL7.4334 mL14.8668 mL74.3340 mL
5 mM0.2973 mL1.4867 mL2.9734 mL14.8668 mL
10 mM0.1487 mL0.7433 mL1.4867 mL7.4334 mL
20 mM0.0743 mL0.3717 mL0.7433 mL3.7167 mL
50 mM0.0297 mL0.1487 mL0.2973 mL1.4867 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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