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Go6976

Catalog No. T6515 CAS 136194-77-9

Synonyms: Gö 6976

Go6976 is a small molecule inhibitor of protein kinase C (PKC). Go6976 has been widely used in biomedical research as a tool to study the role of PKC in various physiological and pathophysiological processes.

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Go6976, CAS 136194-77-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 78.00
5 mg	In stock	$ 192.00
10 mg	In stock	$ 285.00
25 mg	In stock	$ 482.00
50 mg	In stock	$ 687.00
100 mg	In stock	$ 955.00
1 mL * 10 mM (in DMSO)	In stock	$ 198.00

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Purity: 95.89%

Biological Description

Chemical Properties

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Description	Go6976 is a small molecule inhibitor of protein kinase C (PKC). Go6976 has been widely used in biomedical research as a tool to study the role of PKC in various physiological and pathophysiological processes.
Targets&IC50	PKCα:2.3 nM, PKC:7.9 nM, PKCβ1:6.2 nM, PKC:20 nM
In vitro	30 nM Go6976 is sufficient to cause abrogation of S-phase arrest in 6 h and abrogation of G2 arrest followed by lethal mitosis in 24 h. Incubation of cells with 100 nM Go6976 is sufficient to cause complete abrogation of S and G2 arrest at 6 and 24 h, respectively, which is only slightly less potent than in bovine serum[1]. Go6976 is a potent inhibitor of PKC in vitro (IC50 is 20 nM. This compound is structurally related to staurosporine, which is the most potent PKC inhibitor[2]

Synonyms	Gö 6976
Molecular Weight	378.43
Formula	C24H18N4O
CAS No.	136194-77-9

Storage

store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45.0 mg/mL (118.9 mM), Sonication is recommended.

References and Literature

1. Hayamitsu Adachi, et al. Microbial metabolites and derivatives targeted at inflammation and bone diseases therapy: chemistry, biological activity and pharmacology. The Journal of Antibiotics volume 71, pages 60–71 (2018). 2. Qatsha KA, et al. Gö 6976, a selective inhibitor of protein kinase C, is a potent antagonist of human immunodeficiency virus 1 induction from latent/low-level-producing reservoir cells in vitro. Proc Natl Acad Sci U S A. 1993 May 15;90(10):4674-8.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Kinase Inhibitor Library Anti-Cancer Active Compound Library TGF-beta/Smad Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library Bioactive Compound Library Anti-Viral Compound Library Cytoskeletal Signaling Pathway Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Go6976 136194-77-9 Chromatin/Epigenetic Cytoskeletal Signaling PKC Gö 6976 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.