Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lomeguatrib (PaTrin-2), a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 43.00 | |
10 mg | In stock | $ 54.00 | |
25 mg | In stock | $ 95.00 | |
50 mg | In stock | $ 162.00 | |
100 mg | In stock | $ 297.00 | |
500 mg | In stock | $ 743.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 48.00 |
Description | Lomeguatrib (PaTrin-2), a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) . |
Targets&IC50 | MGMT:5 nM |
In vitro | In the A375M human melanoma xenograft model, intraperitoneal injection of Lomeguatrib (20 mg/kg) treatment was found to inhibit ATase activity. |
In vivo | In Raji cells, Lomeguatrib inhibits ATase activity with an IC50 value of 10 nM, while in MCF-7 cells, it effectively inhibits MGMT with an IC50 of 6 nM. |
Synonyms | PaTrin-2 |
Molecular Weight | 326.17 |
Formula | C10H8BrN5OS |
CAS No. | 192441-08-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 60 mg/mL (184 mM)
You can also refer to dose conversion for different animals. More
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Lomeguatrib 192441-08-0 Chromatin/Epigenetic DNA Damage/DNA Repair DNA Alkylation DNA Methyltransferase inhibit DNMTs PaTrin 2 DNA MTases PaTrin-2 PaTrin2 Inhibitor inhibitor