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Lonidamine

Catalog No. T0239 CAS 50264-69-2

Synonyms: AF1890, DICA, Diclondazolic Acid

Lonidamine (Diclondazolic Acid) is an indazole carboxylic acid derivative, principally inhibiting aerobic glycolytic activity, by its effect on mitochondrially-bound hexokinase (HK).

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Lonidamine, CAS 50264-69-2

Pack Size	Availability	Price/USD
2 mg	In stock	$ 33.00
5 mg	In stock	$ 45.00
10 mg	In stock	$ 58.00
25 mg	In stock	$ 75.00
50 mg	In stock	$ 117.00
100 mg	In stock	$ 152.00
500 mg	In stock	$ 373.00
1 g	In stock	$ 555.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 97.36%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Lonidamine (Diclondazolic Acid) is an indazole carboxylic acid derivative, principally inhibiting aerobic glycolytic activity, by its effect on mitochondrially-bound hexokinase (HK).
Targets&IC50	Mitochondrial pyruvate carrier:2.5 μM (Ki)
In vitro	In mice carrying glioma tumors, Lonidamine (160 mg/kg) effectively reduced tumor growth.
In vivo	In both normal and tumor cells, Lonidamine reduces oxygen consumption while augmenting aerobic glycolysis in normal cells, thereby inhibiting aerobic glycolysis in tumor cells. The compound induces apoptosis at a concentration of 50 mg/ml in resistant cell lines, including the human breast cancer cell line MCF-7 ADR(r) and the LB9 multiform glioblastoma cell line, which exhibit resistance to doxorubicin and nitrosourea.

Synonyms	AF1890, DICA, Diclondazolic Acid
Molecular Weight	321.16
Formula	C15H10Cl2N2O2
CAS No.	50264-69-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 32.1 mg/mL (100 mM)

Ethanol: 1.6 mg/mL (5 mM)

References and Literature

1. Floridi A, et al. J Natl Cancer Inst, 1981, 66(3), 497-499. 2. Belzacq AS, et al. Oncogene, 2001, 20(52), 7579-7587. 3. Ravagnan L, et al. Oncogene, 1999, 18(16), 2537-2546. 4. Del Bufalo D, et al. J Clin Invest, 1996, 98(5), 1165-1173. 5. Miccoli L, et al. J Natl Cancer Inst, 1998, 90(18), 1400-1406. 6. Guo L, et al. Inhibition of Mitochondrial Complex II by the Anticancer Agent Lonidamine. J Biol Chem. 2016 Jan 1;291(1):42-57. 7. Nancolas B, et al. The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters. Biochem J. 2016 Apr 1;473(7):929-36.

Citations

1. Chen C, Zhang X, Wang Y, et al. Translational and Post-translational Control of Human Naïve versus Primed Pluripotency. iScience. 2021: 103645.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Inhibitor Library Kinase Inhibitor Library FDA-Approved Kinase Inhibitor Library Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Anti-Neurodegenerative Disease Compound Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Bioactive Compounds Library Max

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Lonidamine 50264-69-2 Apoptosis Metabolism Hexokinase Mitochondrial Metabolism mitochondrial complex AF1890 AF-1890 lactate lung fibrosis Mitochondrial DICA A549 Inhibitor H2030BrM3 AF 1890 inhibit pulmonary fibrosis Diclondazolic Acid inhibitor

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