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Maprotiline hydrochloride

Catalog No. T0172 CAS 10347-81-6

Synonyms: Maprotiline HCl, Psymion, Deprilept, Ludiomil

Maprotiline hydrochloride (Psymion) is a bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effects associated with its use.

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Maprotiline hydrochloride Chemical Structure

Maprotiline hydrochloride, CAS 10347-81-6

Pack Size	Availability	Price/USD
50 mg	In stock	$ 38.00
100 mg	In stock	$ 54.00
200 mg	In stock	$ 75.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 100%

Purity: 99.84%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Maprotiline hydrochloride (Psymion) is a bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effects associated with its use.
In vitro	Maprotiline inhibits HERG channels expressed in HEK cells with an IC50 of 5.2 μM and HERG channels expressed in oocytes with an IC50 of 24 μM. Maprotiline blocks open channels but has no significant effect on closed channels. [1] Maprotiline is atetracyclic antidepressant, which strongly inhibits the uptake of noradrenaline, though it is notable in its lack of inhibition of serotonergic uptake. Maprotiline also has markedly less pronounced alpha-adrenergic blocking activity than amitriptyline. [2] Maprotiline decreases cell viability in a concentration- and time-dependent manner in Neuro-2a cells. Maprotiline induces apoptosis and increases caspase-3 activation. Maprotiline also induces [Ca(2+)](i) increases which involves the mobilization of intracellular Ca(2+) stored in the endoplasmic reticulum. [3]
In vivo	Maprotiline results in significantly increases GluR1 and GluR2/3 subunit expression in the nucleus accumbens and dorsal striatum of mice as detected by immunohistochemistry; and significantly increases GluR1 and GluR2/3 expression in the hippocampus, as demonstrated by Western blot analysis. [4] Maprotiline has a potent anti-inflammatory effect in rats and this effect is linked to the peripheral and supraspinal actions of the drug. [5] Maprotiline impairs learning when administered before training, but no statistically significant effect is evident when administered after training. [6]

Synonyms	Maprotiline HCl, Psymion, Deprilept, Ludiomil
Molecular Weight	313.864
Formula	C20H24ClN
CAS No.	10347-81-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 23 mg/mL (73.3 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 59 mg/mL (188 mM)

References and Literature

1. Ferrer-Villada T, et al. Eur J Pharmacol,2006, 531(1-3), 1-8. 2. Arenas MC, et al. Behav Brain Res,2006, 166(1), 150-158. 3. Jan CR, et al. Toxicology,2013, 304, 1-12. 4. Chang KL, et al. Cancer Lett. 2009 Apr 8;276(1):14-20. 5. Hajhashemi V, et al. Inflamm Res,2010, 59(12), 1053-1059.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Anti-Neurodegenerative Disease Compound Library Inhibitor Library GPCR Compound Library Membrane Protein-targeted Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library NO PAINS Compound Library Antidepressant Compound Library

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Keywords

Maprotiline hydrochloride 10347-81-6 Autophagy GPCR/G Protein Immunology/Inflammation Neuroscience 5-HT Receptor Adrenergic Receptor Norepinephrine AChR Histamine Receptor Maprotiline Inhibitor Maprotiline Hydrochloride Maprotiline HCl inhibit Psymion Deprilept Ludiomil inhibitor

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