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NS 1738

NS 1738
NS 1738 (NSC-213859) is a positive allosteric modulator of the α7-containing neuronal nicotinic acetylcholine receptors (nAChRs)
Catalog No. T7884Cas No. 501684-93-1
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Purity:99.11%
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NS 1738

Purity: 99.11%
Catalog No. T7884Alias NSC 213859Cas No. 501684-93-1

NS 1738 (NSC-213859) is a positive allosteric modulator of the α7-containing neuronal nicotinic acetylcholine receptors (nAChRs)
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Pack SizePriceAvailabilityQuantity
5 mg$47In Stock
10 mg$84In Stock
25 mg$172In Stock
50 mg$293In Stock
100 mg$497In Stock
1 mL x 10 mM (in DMSO)$52In Stock
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Product Introduction

Bioactivity
Description
NS 1738 (NSC-213859) is a positive allosteric modulator of the α7-containing neuronal nicotinic acetylcholine receptors (nAChRs)
Targets&IC50
α7 nAChR:3.4 μM(EC50,in oocyte experiments)
AliasNSC 213859
Chemical Properties
Molecular Weight365.13
FormulaC14H9Cl2F3N2O2
Cas No.501684-93-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 300 mg/mL (821.63 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7388 mL13.6938 mL27.3875 mL136.9375 mL
5 mM0.5478 mL2.7388 mL5.4775 mL27.3875 mL
10 mM0.2739 mL1.3694 mL2.7388 mL13.6938 mL
20 mM0.1369 mL0.6847 mL1.3694 mL6.8469 mL
50 mM0.0548 mL0.2739 mL0.5478 mL2.7388 mL
100 mM0.0274 mL0.1369 mL0.2739 mL1.3694 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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