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NVP-TAE 684

Catalog No. T2251 CAS 761439-42-3

Synonyms: TAE684

NVP-TAE 684 (TAE684) is a excellently effective and specific ALK inhibitor(IC50=3 nM).

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NVP-TAE 684, CAS 761439-42-3

Pack Size	Availability	Price/USD
2 mg	In stock	$ 51.00
5 mg	In stock	$ 81.00
10 mg	In stock	$ 126.00
25 mg	In stock	$ 227.00
50 mg	In stock	$ 342.00
100 mg	In stock	$ 486.00
1 mL * 10 mM (in DMSO)	In stock	$ 119.00

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Purity: 99.91%

Purity: 99.82%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	NVP-TAE 684 (TAE684) is a excellently effective and specific ALK inhibitor(IC50=3 nM).
Targets&IC50	ALK:3 nM
Kinase Assay	In vitro Enzyme Assays.: All in vitro enzyme assays are done at Upstate Biotechnology with the exception of InsR and IGF-1R. To determine the IC50 of TAE684 against InsR and IGF-1R a homogeneous time-resolved fluorescence assay is performed. ATP (10 mM) and 20 mg/ml biotinylated PolyEY (Glu, Tyr 4:1) are combined with 50 nL of serial dilutions of TAE684 (10-500 nM) and 4 ng of InsR enzyme in the presence of the kinase reaction buffer (20 mM Tris譎Cl, pH 7.5/10 mM MgCl2/3 mM MnCl2/1 mM DTT/10 mM NaVO4/0.1 mg/ml of BSA). Assays are incubated for 1 hour at ambient temperature. Reactions are terminated by adding 10 mL of the detection solution containing 50 mM EDTA, 500 mM KF, 0.5 mg/ml of BSA, 5 mg/mL Eu3+ cryptate-labeled anti-phosphotyrosine antibody Mab PT66-K, and 5 mg/mL Streptavidin-XLent. The reaction is incubated for half an hour, and fluorescence signals are read on Analyst GT.
Cell Research	Cells are seeded in 384-well plates (2.5×104 cells per well) and incubated with serial dilutions of TAE684 or DMSO for 2–3 days. Luciferase expression is used as a measure of cell proliferation/survival and is evaluated with the Bright-Glo Luciferase Assay System. IC50 values are generated by using XLFit software.(Only for Reference)

Synonyms	TAE684
Molecular Weight	614.2
Formula	C30H40ClN7O3S
CAS No.	761439-42-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 6.14 mg/mL (10 mM), Sonication is recommended.

References and Literature

1. Galkin AV, et al. Proc Natl Acad Sci U S A, 2007, 104(1), 270-275. 2. Katayama R, et al. Proc Natl Acad Sci U S A, 2011, 108(18), 7535-7540. 3. Schönherr C, et al, Biochem J, 2011, 440(3), 405-413.

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Inhibitor Library Kinase Inhibitor Library Anti-Cancer Active Compound Library Highly Selective Inhibitor Library Preclinical Compound Library Apoptosis Compound Library Angiogenesis related Compound Library Anti-Cancer Compound Library Bioactive Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

NVP-TAE 684 761439-42-3 Angiogenesis Apoptosis Tyrosine Kinase/Adaptors ALK TAE684 Anaplastic lymphoma kinase Anaplastic lymphoma kinase (ALK) NVPTAE 684 inhibit TAE-684 ALK tyrosine kinase receptor NVP-TAE-684 Inhibitor TAE 684 NVP-TAE684 CD246 Cluster of differentiation 246 NVP TAE 684 inhibitor

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