Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ONO-4059 analog (ONO-WG-307)ue is an analogue of ONO-4059, which is a highly potent and selective oral BTK inhibitor with IC50 of 23.9 nM. Phase 1.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 38.00 | |
2 mg | In stock | $ 54.00 | |
5 mg | In stock | $ 89.00 | |
10 mg | In stock | $ 147.00 | |
25 mg | In stock | $ 293.00 | |
50 mg | In stock | $ 487.00 | |
100 mg | In stock | $ 696.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 97.00 |
Description | ONO-4059 analog (ONO-WG-307)ue is an analogue of ONO-4059, which is a highly potent and selective oral BTK inhibitor with IC50 of 23.9 nM. Phase 1. |
Targets&IC50 | BTK:23.9 nM |
In vitro | In TMD-8 cells, ONO-4059 inhibits cell growth with IC50 of 3.59 nM, and induces cell apoptosis. The combination of of ONO-4059 with doxorubicin, etoposide, vincristine or dexamethasone causes the increased apoptosis ratio. [1] |
Synonyms | ONO-4059 analogue, ONO-WG-307, GS-4059 analog |
Molecular Weight | 456.5 |
Formula | C25H24N6O3 |
CAS No. | 1351635-67-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 16 mg/mL (35 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
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ONO-4059 analog 1351635-67-0 Angiogenesis Apoptosis Tyrosine Kinase/Adaptors BTK Inhibitor Btk inhibit ONO4059 ONO 4059 ONO-4059 analogue ONO-WG307 ONO-WG-307 ONO 4059 analog Bruton tyrosine kinase ONO-WG 307 ONO-4059 GS-4059 analog ONO4059 analog inhibitor