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Ranitidine Hydrochloride

Catalog No. T0865 CAS 66357-59-3

Synonyms: AH19065

Ranitidine Hydrochloride (AH19065) is a member of the class of histamine H2-receptor antagonists with antacid activity. Ranitidine is a competitive and reversible inhibitor of the action of histamine, released by enterochromaffin-like (ECL) cells, at the histamine H2-receptors on parietal cells in the stomach, thereby inhibiting the normal and meal-stimulated secretion of stomach acid. In addition, other substances that promote acid secretion have a reduced effect on parietal cells when the H2 receptors are blocked.

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Ranitidine Hydrochloride Chemical Structure

Ranitidine Hydrochloride, CAS 66357-59-3

Pack Size	Availability	Price/USD
25 mg	In stock	$ 30.00
50 mg	In stock	$ 43.00
100 mg	In stock	$ 58.00
200 mg	In stock	$ 67.00
500 mg	In stock	$ 79.00
1 mL * 10 mM (in DMSO)	In stock	$ 65.00

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Purity: 100%

Purity: 99.13%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ranitidine Hydrochloride (AH19065) is a member of the class of histamine H2-receptor antagonists with antacid activity. Ranitidine is a competitive and reversible inhibitor of the action of histamine, released by enterochromaffin-like (ECL) cells, at the histamine H2-receptors on parietal cells in the stomach, thereby inhibiting the normal and meal-stimulated secretion of stomach acid. In addition, other substances that promote acid secretion have a reduced effect on parietal cells when the H2 receptors are blocked.
Targets&IC50	H2 receptor:3.3 ± 1.4 μM
In vitro	Ranitidine sensitizes hepatocytes to killing by cytotoxic products from activated neutrophils, whereas Famotidine lacks this ability. [1] Ranitidine inhibits the production of tumor necrosis factor-alpha (TNF-alpha) in monocytes stimulated with lipopolysaccharide in vitro. [2] Ranitidine reduces the Kel of morphine dose-dependently with a maximum effect of 50%, and increases the relative concentration of morphine-6-glucuronide to morphine-3-glucuronide in isolated guinea pig hepatocytes. Ranitidine gradually decreases the morphine-3-glucuronide/morphine-6-glucuronide ratio by up to 21%. [3]
In vivo	Ranitidine results in liver injury as evidence by increased in serum alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transferase activities within 6 hours after Ranitidine administration in rats. [1] Ranitidine inhibits hepatic ischemia/reperfusion-induced increase in hepatic tissue levels of TNF-alpha, cytokine-induced neutrophil chemoattractant, and hepatic accumulation of neutrophils in rats. [2] Ranitidine cotreatment enhances LPS-induced coagulation prior to liver injury, and anticoagulants reduce liver damage in LPS/RAN-treated rats. Ranitidine /LPS-treated rats results in the formation of fibrin clots in liver sinusoids, and prevention of fibrin deposition associated with reduced hepatocellular injury. Ranitidine cotreatment enhances the LPS-induced TNF increase before the onset of hepatocellular injury in rats. [4] Ranitidine displays anxiolytic effects in the elevated plus-maze as indicated by an increase in time spent in the open arms, more open-arm scanning and more end-excursions in rats. [5]

Synonyms	AH19065
Molecular Weight	350.86
Formula	C13H23ClN4O3S
CAS No.	66357-59-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 142.51mM

DMSO: 199.5 mM

References and Literature

1. Luyendyk JP, et al. J Pharmacol Exp Ther,2003, 307(1), 9-16. 2. Okajima K, et al. J Pharmacol Exp Ther,2002, 301(3), 1157-1165. 3. Aasmundstad TA, et al. Pharmacol Toxicol, 1998, 82(6), 272-279. 4. Tukov FF, et al. Toxicol Sci,2007, 100(1), 267-280. 5. Privou C, et al. Neuropharmacology,1998, 37(8), 12019-1032.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Drug Repurposing Compound Library Anti-Cancer Drug Library GPCR Compound Library Inhibitor Library Anti-Obesity Compound Library Immunology/Inflammation Compound Library Bioactive Compounds Library Max Neuronal Signaling Compound Library Anti-Bacterial Compound Library

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Keywords

Ranitidine Hydrochloride 66357-59-3 GPCR/G Protein Immunology/Inflammation Metabolism Microbiology/Virology Neuroscience Histamine Receptor P450 Antibacterial AH19065 inhibit secretion AH 19065 Gastric CYP2C19 Ranitidine CYPs CYP2C9 Cytochrome P450 H2-receptor Inhibitor AH-19065 Bacterial orally inhibitor

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