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Schisandrol B

Catalog No. T6S1917 CAS 58546-54-6

Synonyms: Gomisin A, TJN-101, Besigomsin, Gamma-Schisandrin, Schizandrol B, Wuweizi alcohol-B

1. Schisandrol B (Besigomsin) may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPKs signaling pathways. 2. Schisandrol B has anti-inflammatory property, potentially result from the inhibition of COX-2, iNOS, IL-6, TNF-α and NO through the down-regulation of RIP2 and NF-κB activation. 3. Schisandrol B induces marked protective effects against hepatic and renal injury induced by CCl(4) exposure through differential regulation of the MAPK signal transduction pathway. 4. Schisandrol B significantly inhibits cell proliferation in a dose-dependent manner, due to cell cycle arrest in the G1 phase with the downregulation of cyclin D1 expression and Retinoblastoma (RB) phosphorylation.

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Schisandrol B, CAS 58546-54-6

Pack Size	Availability	Price/USD
5 mg	In stock	$ 65.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 212.00
50 mg	In stock	$ 318.00
100 mg	In stock	$ 476.00
500 mg	In stock	$ 1,090.00
1 mL * 10 mM (in DMSO)	In stock	$ 72.00

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Purity: 99.32%

Purity: 99.14%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Source

Natural Products > Schisandraceae > Schisandra

Synonyms	Gomisin A, TJN-101, Besigomsin, Gamma-Schisandrin, Schizandrol B, Wuweizi alcohol-B
Molecular Weight	416.46
Formula	C23H28O7
CAS No.	58546-54-6

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (120.06 mM)

References and Literature

1. Hwang, Dae. Protective effects of gomisin A isolated from Schisandra chinensis against CCl4-induced hepatic and renal injury[J]. International Journal of Molecular Medicine, 2013, 31(4):888---898.

Related compound libraries

This product is contained In the following compound libraries：

Traditional Chinese Medicine Monomer Library Inhibitor Library Tobacco Monomer Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Anti-Breast Cancer Compound Library Clinical Compound Library Natural Product Library for HTS

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Keywords

Schisandrol B 58546-54-6 Autophagy Immunology/Inflammation Metabolism NF-Κb P450 Reactive Oxygen Species Gomisin A TJN-101 antioxidant Besigomsin Hepato-protective BCL-2 inhibit P-glycoprotein Inhibitor CYP3A11 anti-inflammatory CCND1 CYP2E1 TJN101 Gamma-Schisandrin anti-diabetic p53 Schizandrol B Wuweizi alcohol-B lignan TJN 101 p21 CYPs Cytochrome P450 Gomisin-A PCNA inhibitor

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