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Silodosin

Catalog No. T1504 CAS 160970-54-7

Synonyms: KAD 3213, KMD 3213

Silodosin (KAD 3213) is an alpha-Adrenergic Blocker. The mechanism of action of silodosin is as an Adrenergic alpha-Antagonist.

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Silodosin, CAS 160970-54-7

Pack Size	Availability	Price/USD
5 mg	In stock	$ 32.00
10 mg	In stock	$ 52.00
25 mg	In stock	$ 76.00
50 mg	In stock	$ 91.00
100 mg	In stock	$ 108.00
200 mg	In stock	$ 135.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.76%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Silodosin (KAD 3213) is an alpha-Adrenergic Blocker. The mechanism of action of silodosin is as an Adrenergic alpha-Antagonist.
Targets&IC50	α1D-adrenoceptor:2 nM (Ki), α1B-adrenoceptor:21 nM (Ki), α1A-adrenoceptor:0.036 nM (Ki)
In vitro	Silodosin (0.1-0.3 mg/kg) significantly reduces intralumenal ureteral pressure by 21-37% in obstruction-induced scenarios, whereas Phentolamine (0.03-0.1 mg/kg) can increase it by 18-40%. In dogs with benign prostatic hyperplasia, Silodosin (0.3-300 mg/kg) dose-dependently inhibits the increase in urethral pressure induced by pelvic nerve stimulation without notable hypotensive effects. In rabbit lower urinary tract tissues, Silodosin markedly antagonizes contractions induced by norepinephrine (including in the prostate, urethra, and bladder trigone, with PA(2) or pKb values of 9.60, 8.71, and 9.35, respectively). Oral administration of Silodosin in rats significantly inhibits the increase in urethral pressure caused by phenylephrine at 12 h, 18 h, and 24 h post-administration compared to the control group. Silodosin exhibits inhibitory effects on isolated contractions of rat and human ureters and possesses strong functional selectivity for relieving pressure in ureteral obstruction in rats.
In vivo	Silodosin and tadalafil synergistically inhibit neurally-mediated contraction effects in human and rat ex vivo prostates. Compared to tamsulosin hydrochloride, naftopidil, or prazosin hydrochloride, Silodosin exhibits higher selectivity for the α(1A)-AR subtype, with the affinity order being highest for tamsulosin hydrochloride, followed by Silodosin, prazosin hydrochloride, or naftopidil.

Synonyms	KAD 3213, KMD 3213
Molecular Weight	495.53
Formula	C25H32F3N3O4
CAS No.	160970-54-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 92 mg/mL (185.7 mM)

Ethanol: 92 mg/mL (185.7 mM)

References and Literature

1. Tatemichi S, et al. Yakugaku Zasshi,2006, 126, 209-216. 2. Buono R, et al. Eur J Pharmacol,2014, 744, 42-51. 3. Kobayashi M, et al. Yakugaku Zasshi,2006, 126, 231-236. 4. Shiozaki A, et al. J Physiol Sci,2006, 56(6), 401-406. 5. Kobayashi S, et al. Eur J Pharmacol,2009, 613(1-3), 135-140.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Highly Selective Inhibitor Library Membrane Protein-targeted Compound Library Inhibitor Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library GPCR Compound Library Anti-Cancer Drug Library EMA Approved Drug Library Drug Repurposing Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Keywords

Silodosin 160970-54-7 GPCR/G Protein Neuroscience Adrenergic Receptor Beta Receptor symptoms KMD3213 Inhibitor inhibit lower cancer prostatic KAD 3213 LUTS tract KAD-3213 benign urinary KMD 3213 hyperplasia KAD3213 BPH KMD-3213 inhibitor

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