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Sulfanilamide
Catalog No. T0123Cas No. 63-74-1
Alias UK-124, Sulphanilamide
Sulfanilamide (UK-124) can competitively inhibit bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM.
Sulfanilamide
Catalog No. T0123Alias UK-124, SulphanilamideCas No. 63-74-1
Sulfanilamide (UK-124) can competitively inhibit bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 500 mg | $30 | In Stock | |
| 1 g | $37 | In Stock | |
| 5 g | $53 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $39 | In Stock |
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Purity:99.94%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Sulfanilamide (UK-124) can competitively inhibit bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM. |
| Targets&IC50 | DHPS:320 μM |
| In vitro | Sulfanilamide was able to inhibit a recombinant yeast strain with a wild-type FOL1 gene with an IC50 of 286.8 μg/mL, but a single mutation in the active region of the fungal dihydropyrimidine synthase from 55Trp to 55Ala or 57Pro to 57Ser resulted in resistance to Sulfanilamide with an IC50 >800 μg/mL. /The sulfonamide group of Sulfanilamide inhibits dihydropyridine synthase purified from E. coli. p-Aminobenzoic acid synthesis is used for essential folic acid in the synthesis of purines, pyrimidines, and other amino acids. The IC50 of Sulfanilamide was 320 μM for dihydropyridine synthase, and the Km was 2.5 uM for PABA. Sulfanilamide was able to inhibit the growth of Plasmodium falciparum-containing pKOS-pfPPPK-DHPS(His) bacterial cells to a certain extent with an IC50 of 380 uM. |
| In vivo | Sulfanilamide was able to inhibit a recombinant yeast strain with a wild-type FOL1 gene with an IC50 of 286.8 μg/mL, but a single mutation in the active region of the fungal dihydropyrimidine synthase from 55Trp to 55Ala or 57Pro to 57Ser resulted in resistance to Sulfanilamide with an IC50 >800 μg/mL. /The sulfonamide group of Sulfanilamide inhibits dihydropyridine synthase purified from E. coli. p-Aminobenzoic acid synthesis is used for essential folic acid in the synthesis of purines, pyrimidines, and other amino acids. The IC50 of Sulfanilamide was 320 μM for dihydropyridine synthase, and the Km was 2.5 uM for PABA. Sulfanilamide was able to inhibit the growth of Plasmodium falciparum-containing pKOS-pfPPPK-DHPS(His) bacterial cells to a certain extent with an IC50 of 380 uM. |
| Alias | UK-124, Sulphanilamide |
| Molecular Weight | 172.2 |
| Formula | C6H8N2O2S |
| Cas No. | 63-74-1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (290.36 mM)  H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: 14 mg/mL (81.3 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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