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Upamostat

Catalog No. T13257 CAS 590368-25-5

Upamostat is an inhibitor of a serine protease and is a urokinase plasminogen activator (uPA) inhibitor.

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Upamostat, CAS 590368-25-5

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Upamostat is an inhibitor of a serine protease and is a urokinase plasminogen activator (uPA) inhibitor.

In vitro

Upamostat is an inhibitor of urokinase plasminogen activator (uPA). Upamostat is the oral prodrug of the active metabolite WX-UK1, a novel inhibitor of uPA [1]. Upamostat inhibits the urokinase-type plasminogen activator (uPA) system, and plays a major role in tumor invasion and metastasis. Upamostat is the orally available amidoxime- (i.e. hydroxyamidine-) prodrug of the pharmacologically active form, WX-UK1 [2].

Molecular Weight	629.81
Formula	C32H47N5O6S
CAS No.	590368-25-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 250 mg/mL (396.95 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Heinemann V, et al. Phase II randomised proof-of-concept study of the urokinase inhibitor upamostat (WX-671) in combination with gemcitabine compared with gemcitabine alone in patients with non-resectable, locally advanced pancreatic cancer. Br J Cancer. 2013 Mar 5;108(4):766-70. 2. Froriep D, et al. Activation of the anti-cancer agent upamostat by the mARC enzyme system. Xenobiotica. 2013 Sep;43(9):780-4. 3. Park C, et al. HPLC-MS/MS analysis of mesupron and its application to a pharmacokinetic study in rats. J Pharm Biomed Anal. 2018 Feb 20;150:39-42.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Preclinical Compound Library Drug Repurposing Compound Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Bioactive Compound Library Clinical Compound Library

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Related compounds with same targets

GW-6604 TM5007 Toddalolactone TM5275 sodium TM5441 Loureirin B UK-371804 Aleplasinin

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Upamostat 590368-25-5 代谢蛋白酶体细胞周期 PAI-1 Serine Protease Serine/threonin kinase inhibit Threonine proteases WX 671 Inhibitor Ser/Thr Protease Plasminogen activator inhibitor-1 Serine endopeptidases WX-671 WX671 Serine proteases inhibitor

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