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VU0467154

Catalog No. T17244 CAS 1451993-15-9

VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor.

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VU0467154, CAS 1451993-15-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 41.00
2 mg	In stock	$ 59.00
5 mg	In stock	$ 97.00
10 mg	In stock	$ 133.00
25 mg	In stock	$ 263.00
50 mg	In stock	$ 446.00
100 mg	In stock	$ 657.00
1 mL * 10 mM (in DMSO)	In stock	$ 107.00

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Purity: 98.28%

Purity: 98.05%

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Description	VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor.
Targets&IC50	M4 mAChR:6(pEC50,Cynomolgus monkey), M4 mAChR:6.2(pEC50,human), M4 mAChR:7.75(pEC50, rat)
In vitro	VU0467154 potentiates the response to ACh with pEC50s of 7.75(rat), 6.2(human) and 6(cynomolgus monkey) for M4 receptor, respectively. VU0467154 does not potentiate the ACh response at rat and human M1, M2, M3, or M5[1].
In vivo	VU0467154 produced a robust dose-dependent reversal of MK-801-induced hyperlocomotion and deficits in preclinical models of associative learning and memory functions, including the touchscreen pairwise visual discrimination task in wild-type mice, but failed to reverse these stimulant-induced deficits in M4 KO mice[1]. VU0467154 also enhanced the acquisition of both contextual and cue-mediated fear conditioning when administered alone in wild-type mice[1].

Molecular Weight	444.45
Formula	C17H15F3N4O3S2
CAS No.	1451993-15-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (112.50 mM)

References and Literature

1. Bubser M, et al. Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodents. ACS Chem Neurosci. 2014 Oct 15;5(10):920-42.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Membrane Protein-targeted Compound Library Neurotransmitter Receptor Compound Library Neuronal Signaling Compound Library Bioactive Compound Library Bioactive Compounds Library Max Anti-Parkinson's Disease Compound Library Anti-Alzheimer's Disease Compound Library

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Keywords

VU0467154 1451993-15-9 Neuroscience AChR VU 0467154 Muscarinic acetylcholine receptor VU-0467154 mAChR inhibit Inhibitor inhibitor

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