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AAL-993

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COA HPLC

AAL-993

Catalog No. T21593Cas No. 269390-77-4

AAL-993 is a potent VEGFR inhibitor with IC50s of 130 nM, 23 nM and 18 nM for VEGFR1, VEGFR2 and VEGFR3, respectively. AAL993 has a weak inhibitory effect on other tyrosine kinases. AAL993 also shows potent antiangiogenic and antitumor activities.

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Pack Size	Price	Availability
1 mg	$38	In Stock
5 mg	$89	In Stock
10 mg	$148	In Stock
25 mg	$289	In Stock
50 mg	$455	In Stock
100 mg	$672	In Stock
500 mg	$1,430	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock

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Product Introduction

Bioactivity

Description	AAL-993 is a potent VEGFR inhibitor with IC50s of 130 nM, 23 nM and 18 nM for VEGFR1, VEGFR2 and VEGFR3, respectively. AAL993 has a weak inhibitory effect on other tyrosine kinases. AAL993 also shows potent antiangiogenic and antitumor activities.
In vitro	AAL993 suppressed HIF-1α expression through the inhibition of ERK without affecting Akt phosphorylation[1].
In vivo	AAL993 (24-100 mg/kg; p.o.) inhibited both the growth of the primary tumor as well as the formation of spontaneous peripheral metastases in B16 melanoma xenograft model[2]. AAL993 potently inhibited VEGF-induced angiogenesis with an ED50 value of 7 mg/kg in an implant model[2].

Chemical Properties

Molecular Weight	371.36
Formula	C20H16F3N3O
Cas No.	269390-77-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (148.1 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6928 mL	13.4640 mL	26.9280 mL	134.6402 mL
5 mM	0.5386 mL	2.6928 mL	5.3856 mL	26.9280 mL
10 mM	0.2693 mL	1.3464 mL	2.6928 mL	13.4640 mL
20 mM	0.1346 mL	0.6732 mL	1.3464 mL	6.7320 mL
50 mM	0.0539 mL	0.2693 mL	0.5386 mL	2.6928 mL
100 mM	0.0269 mL	0.1346 mL	0.2693 mL	1.3464 mL

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