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Arotinolol hydrochloride
🥰Excellent
Catalog No. T30140Cas No. 68377-91-3
Alias Arotinolol HCl
Arotinolol hydrochloride（Arotinolol HCl） is a non-selective α/β-adrenergic receptor blocker.Arotinolol hydrochloride inhibits the binding of the radioligand 125I-ICYP to the 5HT1B-hydroxytryptamine receptor. Arotinolol hydrochloride is an antihypertensive and anti-obesity agent that improves aortic stiffness in rats and is used to study obesity-related diseases.
Arotinolol hydrochloride
🥰Excellent
Purity: 99.84%
Catalog No. T30140Alias Arotinolol HClCas No. 68377-91-3
Arotinolol hydrochloride（Arotinolol HCl） is a non-selective α/β-adrenergic receptor blocker.Arotinolol hydrochloride inhibits the binding of the radioligand 125I-ICYP to the 5HT1B-hydroxytryptamine receptor. Arotinolol hydrochloride is an antihypertensive and anti-obesity agent that improves aortic stiffness in rats and is used to study obesity-related diseases.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $48 | In Stock | |
| 5 mg | $108 | In Stock | |
| 10 mg | $162 | In Stock | |
| 25 mg | $268 | In Stock | |
| 50 mg | $392 | In Stock | |
| 100 mg | $588 | In Stock | |
| 500 mg | $1,250 | In Stock |
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Purity:99.84%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Arotinolol hydrochloride（Arotinolol HCl） is a non-selective α/β-adrenergic receptor blocker.Arotinolol hydrochloride inhibits the binding of the radioligand 125I-ICYP to the 5HT1B-hydroxytryptamine receptor. Arotinolol hydrochloride is an antihypertensive and anti-obesity agent that improves aortic stiffness in rats and is used to study obesity-related diseases. |
| In vitro | Arotinolol HCl shows its potency for inhibiting the binding of the same radioligand to the 5HT1B-serotonergic receptor site, Arotinolol HCl displaces 125I-ICYP binding to 5HT1B-receptors with the pKi values of 7.97 and 8.16 respectively for β1 and β2 adrenergic receptors.[3] Arotinolol HCl shows its selectivity of β-adrenergic receptors, the result of Arotinolol HCl for β1 and β2 adrenoceptors in 125I-ICYP binding to rat cerebral cortical membranes with pKi value of 9.74 and 9.26 respectively. The selective of β1 and β2 is equal.[3] |
| In vivo | Arotinolol HCl (200 mg/kg; oral gavage; 8 weeks) can significantly decrease central arterial pressure (CAP) and pulse wave velocity (PWV), in addition, it reduces aortic collagen depositions and finally improves arterial stiffness in SHR mice.[3] |
| Alias | Arotinolol HCl |
| Molecular Weight | 408 |
| Formula | C15H22ClN3O2S3 |
| Cas No. | 68377-91-3 |
| Smiles | Cl.CC(C)(C)NCC(O)CSc1nc(cs1)-c1ccc(s1)C(N)=O |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (134.8 mM)  | |||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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