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Baloxavir

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Catalog No. T14495Cas No. 1985605-59-1
Alias S-033447, Baloxavir acid

Baloxavir (S-033447) is a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit.

Baloxavir

Baloxavir

🥰Excellent
Purity: 99.89%
Catalog No. T14495Alias S-033447, Baloxavir acidCas No. 1985605-59-1
Baloxavir (S-033447) is a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit.
Pack SizePriceAvailabilityQuantity
1 mg$71In Stock
5 mg$173In Stock
10 mg$274In Stock
25 mg$527In Stock
50 mg$671In Stock
100 mg$956In Stock
200 mg$1,290In Stock
1 mL x 10 mM (in DMSO)$184In Stock
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Purity:99.89%
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Product Introduction

Bioactivity
Description
Baloxavir (S-033447) is a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit.
In vitro
Baloxavir (BXA) inhibits viral RNA transcription via selective inhibition of cap-dependent endonuclease (CEN) activity in enzymatic assays, and inhibits viral replication in infected cells without cytotoxicity in cytopathic effect assays, and it also inhibits cap-dependent endonuclease (CEN) and CEN/RdRp activities with IC50 values of 2.5 nM and 1.6 nM, respectively, while low potency (IC50 >40 nM) is observed against RdRp activity[2]. The median EC50 values at baseline for Baloxavir (BXA) are 17.96 nM for A/H1N1pdm, 4.48 nM for A/H3N2, and 18.67 nM for type B virus[1]. Baloxavir shows high potency against influenza A and B viruses with mean EC90 of 0.46 - 0.98 nM and 2.2-3.4 nM, respectively[2] and it also shows broad potency against various subtypes of influenza A viruses (H1N2, H5N1, H5N2, H5N6, H7N9 and H9N2). Additionally, serial passages of the viruses in the presence of Baloxavir result in isolation of PA/I38T variants with reduced BXA susceptibility[2]. Baloxavir (BXA) has a high inhibitory potency against CEN activity of the tested viral ribonucleoprotein complexes (vRNPs) from influenza A and B viruses with mean IC50 values of 1.4-3.1 nM and 4.5-8.9 nM, respectively, indicating that Baloxavir has broad spectrum activities.
AliasS-033447, Baloxavir acid
Chemical Properties
Molecular Weight483.49
FormulaC24H19F2N3O4S
Cas No.1985605-59-1
SmilesOc1c2C(=O)N3CCOC[C@H]3N([C@@H]3c4ccccc4SCc4c(F)c(F)ccc34)n2ccc1=O
Relative Density.1.63 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 45 mg/mL (93.07 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0683 mL10.3415 mL20.6830 mL103.4148 mL
5 mM0.4137 mL2.0683 mL4.1366 mL20.6830 mL
10 mM0.2068 mL1.0341 mL2.0683 mL10.3415 mL
20 mM0.1034 mL0.5171 mL1.0341 mL5.1707 mL
50 mM0.0414 mL0.2068 mL0.4137 mL2.0683 mL

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