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Broflanilide
🥰Excellent
Catalog No. T10618Cas No. 1207727-04-5
Broflanilide is metabolized to desmethyl-broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin GABA receptor and inhibits S. litura RDL GABAR with IC50 of 1.3 nM.
Broflanilide
🥰Excellent
Purity: 98.95%
Catalog No. T10618Cas No. 1207727-04-5
Broflanilide is metabolized to desmethyl-broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin GABA receptor and inhibits S. litura RDL GABAR with IC50 of 1.3 nM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $48 | In Stock | |
| 5 mg | $113 | In Stock | |
| 10 mg | $189 | In Stock | |
| 25 mg | $376 | In Stock | |
| 50 mg | $619 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $133 | In Stock |
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Purity:98.95%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Broflanilide is metabolized to desmethyl-broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin GABA receptor and inhibits S. litura RDL GABAR (IC50: 1.3 nM). |
| Targets&IC50 | GlyR α1 (A288Gβ):0.706 μM, GlyR α1 (A288G):0.149 μM, GABA receptor:1.3 nM(S. litura RDL), GABAA α1β3γ2:3 μM(mammalian), GlyR:3 μM(human) |
| In vitro | Broflanilide, an insecticide metabolized to desmethyl-broflanilide, exhibits weak activity against human GABAA α1β2γ2, mammalian GABAA α1β3γ2, and human glycine receptor (GlyR) α1β with IC50s >3 μM, and less potent inhibition of GlyR α1-A288Gβ and GlyR α1-A288G with IC50s of 0.706 μM and 0.149 μM, respectively. |
| Molecular Weight | 663.29 |
| Formula | C25H14BrF11N2O2 |
| Cas No. | 1207727-04-5 |
| Smiles | CN(C(=O)c1ccccc1)c1cccc(C(=O)Nc2c(Br)cc(cc2C(F)(F)F)C(F)(C(F)(F)F)C(F)(F)F)c1F |
| Relative Density. | 1.625 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 225 mg/mL (339.22 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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