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CAY10594

🥰Excellent
Catalog No. T7280Cas No. 1130067-34-3

CAY10594 is a potent phospholipase D2(PLD2) inhibitor. CAY10594 ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK axis.

CAY10594

CAY10594

🥰Excellent
Purity: 98%
Catalog No. T7280Cas No. 1130067-34-3
CAY10594 is a potent phospholipase D2(PLD2) inhibitor. CAY10594 ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK axis.
Pack SizePriceAvailabilityQuantity
1 mg$76In Stock
5 mg$163In Stock
10 mg$278In Stock
25 mg$497In Stock
50 mg$723In Stock
100 mg$987In Stock
1 mL x 10 mM (in DMSO)$178In Stock
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Purity:98%
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Product Introduction

Bioactivity
Description
CAY10594 is a potent phospholipase D2(PLD2) inhibitor. CAY10594 ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK axis.
In vivo
CAY10594 administration markedly blocked the acute liver injury in a dose-dependent manner, showing almost complete inhibition with 8?mg/kg of CAY10594. During the pathological progress of acute liver injury, GSH levels are decreased, and this is significantly recovered upon the administration of CAY10594 at 6?hours post APAP challenge. GSK-3β (Serine 9)/JNK phosphorylation is mainly involved in APAP-induced liver injury. CAY10594 administration strongly blocked GSK-3β (Serine 9)/JNK phosphorylation in the APAP-induced acute liver injury model. Consistently, sustained JNK activation in the cytosol and mitochondria from hepatocytes were also decreased in CAY10594-treated mice. Many types of immune cells are also implicated in APAP-induced liver injury. However, neutrophil and monocyte populations were not different between vehicle- and CAY10594-administered mice which are challenged with APAP. Therapeutic administration of CAY10594 also significantly attenuated liver damage caused by the APAP challenge, eliciting an enhanced survival rate[1].
Animal Research
Mice were fasted for 16?hours before APAP injection. APAP (500?mg/kg) was administered with oral gavage in mice. CAY10594 (N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4,5]dec-8-yl)ethyl]-2-naphthalene carboxamide)23 was dissolved in 1% DMSO and intraperitoneally administered to mice 30?minutes prior to APAP injection for examining protective effects or after 3?hours from APAP challenge for investigating therapeutic effects of CAY10594[1].
Chemical Properties
Molecular Weight428.53
FormulaC26H28N4O2
Cas No.1130067-34-3
SmilesO=C(NCCN1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccc2ccccc2c1
Relative Density.1.29 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 20 mg/mL (46.7 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3336 mL11.6678 mL23.3356 mL116.6779 mL
5 mM0.4667 mL2.3336 mL4.6671 mL23.3356 mL
10 mM0.2334 mL1.1668 mL2.3336 mL11.6678 mL
20 mM0.1167 mL0.5834 mL1.1668 mL5.8339 mL

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