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Crolibulin

🥰Excellent
Catalog No. T15012Cas No. 1000852-17-4
Alias EPC2407

Crolibulin (EPC2407) is an inhibitor of small molecule tubulin polymerization.

Crolibulin

Crolibulin

🥰Excellent
Purity: 98.19%
Catalog No. T15012Alias EPC2407Cas No. 1000852-17-4
Crolibulin (EPC2407) is an inhibitor of small molecule tubulin polymerization.
Pack SizePriceAvailabilityQuantity
1 mg$58In Stock
2 mg$84In Stock
5 mg$139In Stock
10 mg$228In Stock
25 mg$396In Stock
50 mg$591In Stock
100 mg$793In Stock
1 mL x 10 mM (in DMSO)$153In Stock
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Purity:98.19%
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Product Introduction

Bioactivity
Description
Crolibulin (EPC2407) is an inhibitor of small molecule tubulin polymerization.
Targets&IC50
Tubulin polymerization:0.52 μM
In vitro
Crolibulin demonstrates notable cytotoxic effects on HT-29 cells, achieving an IC50 value of 0.52 μM[2]. It is effective against a range of experimental tumors and significantly inhibits mitosis during the G2/M phase[2].
AliasEPC2407
Chemical Properties
Molecular Weight417.26
FormulaC18H17BrN4O3
Cas No.1000852-17-4
SmilesCOc1cc(cc(Br)c1OC)[C@H]1C(C#N)=C(N)Oc2c(N)c(N)ccc12
Relative Density.1.62 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 120 mg/mL (287.59 mM), Sonication and heating are recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3966 mL11.9829 mL23.9659 mL119.8294 mL
5 mM0.4793 mL2.3966 mL4.7932 mL23.9659 mL
10 mM0.2397 mL1.1983 mL2.3966 mL11.9829 mL
20 mM0.1198 mL0.5991 mL1.1983 mL5.9915 mL
50 mM0.0479 mL0.2397 mL0.4793 mL2.3966 mL
100 mM0.0240 mL0.1198 mL0.2397 mL1.1983 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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