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DAPTA

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Purity:100%

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COA HNMR LCMS

DAPTA

Catalog No. T7624Cas No. 106362-34-9

DAPTA (Adaptavir) is an inhibitor of CCR5, shows potent anti-HIV activities.

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Pack Size	Price	Availability
1 mg	$47	In Stock
5 mg	$89	In Stock
10 mg	$155	In Stock
25 mg	$297	In Stock
50 mg	$443	In Stock
100 mg	$639	In Stock

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Product Introduction

Bioactivity

Description	DAPTA (Adaptavir) is an inhibitor of CCR5, shows potent anti-HIV activities.
In vitro	D-Ala-peptide T-amide (DAPTA), or Peptide T, named for its high threonine content (ASTTTNYT), is a synthetic peptide comprised of eight amino acids (185-192) of the gp120 V2 region and functions as a viral entry inhibitor by targeting selectively CCR5.?The anti-HIV-1 activity of DAPTA was evaluated in M/M infected with R5 HIV-1 strains.?DAPTA at 10(-9) M inhibited HIV-1 replication in M/M by > 90%.?PCR analysis of viral cDNA in M/M showed that DAPTA blocks HIV entry and in this way prevents HIV-1 infection.?Moreover, DAPTA acts as a strong inhibitor and was more active than the non-peptidic CCR5 antagonist TAK-779 in inhibiting apoptosis (mediated by RS HIV-1 strains produced and released by infected M/M) on a neuroblastoma cell line[1]
Alias	DAPTA(TFA), D-Ala-peptide T-amide, Adaptavir

Chemical Properties

Molecular Weight	856.88
Formula	C35H56N10O15
Cas No.	106362-34-9

Storage & Solubility Information

Storage

keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10mM

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1670 mL	5.8351 mL	11.6702 mL	58.3512 mL
5 mM	0.2334 mL	1.1670 mL	2.3340 mL	11.6702 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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