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DAPTA
🥰Excellent
Catalog No. T7624Cas No. 106362-34-9
Alias D-Ala-peptide T-amide, Adaptavir
DAPTA (Adaptavir) is an inhibitor of CCR5, shows potent anti-HIV activities.
DAPTA
🥰Excellent
Purity: 100%
Catalog No. T7624Alias D-Ala-peptide T-amide, AdaptavirCas No. 106362-34-9
DAPTA (Adaptavir) is an inhibitor of CCR5, shows potent anti-HIV activities.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $47 | In Stock | |
| 5 mg | $89 | In Stock | |
| 10 mg | $155 | In Stock | |
| 25 mg | $297 | In Stock | |
| 50 mg | $443 | In Stock | |
| 100 mg | $639 | In Stock |
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CitedSelect Batch
Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | DAPTA (Adaptavir) is an inhibitor of CCR5, shows potent anti-HIV activities. |
| Targets&IC50 | Gp120 BaL/sCD4-CCR5:55 pM (IC50, in Cf2Th/synR5 cells), Gp120CM CM235/sCD4-CCR5:0.32 nM (IC50, in Cf2Th/synR5 cells) |
| In vitro | D-Ala-peptide T-amide (DAPTA), or Peptide T, named for its high threonine content (ASTTTNYT), is a synthetic peptide comprised of eight amino acids (185-192) of the gp120 V2 region and functions as a viral entry inhibitor by targeting selectively CCR5.?The anti-HIV-1 activity of DAPTA was evaluated in M/M infected with R5 HIV-1 strains.?DAPTA at 10(-9) M inhibited HIV-1 replication in M/M by > 90%.?PCR analysis of viral cDNA in M/M showed that DAPTA blocks HIV entry and in this way prevents HIV-1 infection.?Moreover, DAPTA acts as a strong inhibitor and was more active than the non-peptidic CCR5 antagonist TAK-779 in inhibiting apoptosis (mediated by RS HIV-1 strains produced and released by infected M/M) on a neuroblastoma cell line[1] |
| Alias | D-Ala-peptide T-amide, Adaptavir |
| Molecular Weight | 856.88 |
| Formula | C35H56N10O15 |
| Cas No. | 106362-34-9 |
| Smiles | C[C@@H](O)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](C)N)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(N)=O |
| Relative Density. | 1.415g/cm3 |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 10 mM | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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