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Didanosine
🥰Excellent
Catalog No. T2578Cas No. 69655-05-6
Alias ddI, 2',3'-Dideoxyinosine
Didanosine (ddI) is a nucleoside reverse transcriptase inhibitor analog of adenosine (IC50: 0.49 μM).
Didanosine
🥰Excellent
Purity: 99.81%
Catalog No. T2578Alias ddI, 2',3'-DideoxyinosineCas No. 69655-05-6
Didanosine (ddI) is a nucleoside reverse transcriptase inhibitor analog of adenosine (IC50: 0.49 μM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $33 | In Stock | |
| 25 mg | $51 | In Stock | |
| 50 mg | $68 | In Stock | |
| 100 mg | $101 | In Stock | |
| 500 mg | $253 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $37 | In Stock |
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CitedSelect Batch
Purity:99.81%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Didanosine (ddI) is a nucleoside reverse transcriptase inhibitor analog of adenosine (IC50: 0.49 μM). |
| Targets&IC50 | Reverse transcriptase:0.49 μM |
| In vivo | In cultured human muscle cells, Didanosine induced accumulation of cytoplasmic lipid droplets, increased lactate production, and decreased SDH (part of complex II) and COX (complex IV) activity. In HIV target cells, Didanosine was converted to its active form, deoxyadenosine-5'-triphosphate (ddATP). In dissociated DRG cells in culture, Didanosine dose-dependently induced reductions in the number of neurites, the length of each neurite in the longest neurite, and the total length of the neurite. In dissociated DRG neurons, Didanosine dose-dependently induced neurite retraction or axon loss, suggesting that desipramine is useful in the development of peripheral neuropathy. In cultured human TK6 lymphoblastoid cells, Didanosine induced mutagenicity of the thymidine kinase gene induced by zidovudine. |
| Alias | ddI, 2',3'-Dideoxyinosine |
| Molecular Weight | 236.23 |
| Formula | C10H12N4O3 |
| Cas No. | 69655-05-6 |
| Smiles | O=C1C2=C(N(C=N2)[C@@H]3O[C@H](CO)CC3)NC=N1 |
| Relative Density. | 1.2917 g/cm3 (Estimated) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: < 1 mg/mL (insoluble or slightly soluble) DMSO: 70 mg/mL (296.32 mM), Sonication is recommended.  H2O: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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