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Didanosine

🥰Excellent
Catalog No. T2578Cas No. 69655-05-6
Alias ddI, 2',3'-Dideoxyinosine

Didanosine (ddI) is a nucleoside reverse transcriptase inhibitor analog of adenosine (IC50: 0.49 μM).

Didanosine

Didanosine

🥰Excellent
Purity: 99.81%
Catalog No. T2578Alias ddI, 2',3'-DideoxyinosineCas No. 69655-05-6
Didanosine (ddI) is a nucleoside reverse transcriptase inhibitor analog of adenosine (IC50: 0.49 μM).
Pack SizePriceAvailabilityQuantity
10 mg$33In Stock
25 mg$51In Stock
50 mg$68In Stock
100 mg$101In Stock
500 mg$253In Stock
1 mL x 10 mM (in DMSO)$37In Stock
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Purity:99.81%
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Product Introduction

Bioactivity
Description
Didanosine (ddI) is a nucleoside reverse transcriptase inhibitor analog of adenosine (IC50: 0.49 μM).
Targets&IC50
Reverse transcriptase:0.49 μM
In vivo
In cultured human muscle cells, Didanosine induced accumulation of cytoplasmic lipid droplets, increased lactate production, and decreased SDH (part of complex II) and COX (complex IV) activity. In HIV target cells, Didanosine was converted to its active form, deoxyadenosine-5'-triphosphate (ddATP). In dissociated DRG cells in culture, Didanosine dose-dependently induced reductions in the number of neurites, the length of each neurite in the longest neurite, and the total length of the neurite. In dissociated DRG neurons, Didanosine dose-dependently induced neurite retraction or axon loss, suggesting that desipramine is useful in the development of peripheral neuropathy. In cultured human TK6 lymphoblastoid cells, Didanosine induced mutagenicity of the thymidine kinase gene induced by zidovudine.
AliasddI, 2',3'-Dideoxyinosine
Chemical Properties
Molecular Weight236.23
FormulaC10H12N4O3
Cas No.69655-05-6
SmilesO=C1C2=C(N(C=N2)[C@@H]3O[C@H](CO)CC3)NC=N1
Relative Density.1.2917 g/cm3 (Estimated)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 70 mg/mL (296.32 mM), Sonication is recommended.
H2O: < 1 mg/mL (insoluble or slightly soluble)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.2332 mL21.1658 mL42.3316 mL211.6581 mL
5 mM0.8466 mL4.2332 mL8.4663 mL42.3316 mL
10 mM0.4233 mL2.1166 mL4.2332 mL21.1658 mL
20 mM0.2117 mL1.0583 mL2.1166 mL10.5829 mL
50 mM0.0847 mL0.4233 mL0.8466 mL4.2332 mL
100 mM0.0423 mL0.2117 mL0.4233 mL2.1166 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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2 Enter the in vivo formulation:
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