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DOPEXAMINE

🥰Excellent
Catalog No. T8653Cas No. 86197-47-9

Dopexamine is a dopaminergic agonist

DOPEXAMINE

DOPEXAMINE

🥰Excellent
Purity: 99.42%
Catalog No. T8653Cas No. 86197-47-9
Dopexamine is a dopaminergic agonist
Pack SizePriceAvailabilityQuantity
1 mg$133In Stock
2 mg$198In Stock
5 mg$298In Stock
10 mg$453In Stock
25 mg$747In Stock
50 mg$1,050In Stock
100 mg$1,420In Stock
1 mL x 10 mM (in DMSO)$323In Stock
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Purity:99.42%
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Product Introduction

Bioactivity
Description
Dopexamine is a dopaminergic agonist
In vivo
Dopexamine hydrochloride has interesting vasodilator properties, with marked intrinsic agonist activity at beta-2 adrenoreceptors and a lesser agonist activity at dopaminergic receptors (DA1 and DA2).?Dopexamine hydrochloride is responsible for an inhibition of neuronal re-uptake of catecholamines (uptake-1), producing an indirect stimulation of cardiac beta 1-receptors.?Dopexamine hydrochloride improves cardiac performance by a marked vasodilation and a mild inotropic activity.?The specific activity at dopaminergic receptors increases cerebral, myocardial, splanchnic and renal blood flows.?These haemodynamic effects are associated with an increase in diuresis and natriuresis.?These benefits are achieved without side effects such as an increased myocardial oxygen consumption, although induced tachycardia may be responsible for chest pain/anginae pain in patients with ischaemic heart disease[1].
Chemical Properties
Molecular Weight356.5
FormulaC22H32N2O2
Cas No.86197-47-9
SmilesC(CNCCCCCCNCCC1=CC=CC=C1)C2=CC(O)=C(O)C=C2
Relative Density.1.081 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 55 mg/ml (154.28 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8050 mL14.0252 mL28.0505 mL140.2525 mL
5 mM0.5610 mL2.8050 mL5.6101 mL28.0505 mL
10 mM0.2805 mL1.4025 mL2.8050 mL14.0252 mL
20 mM0.1403 mL0.7013 mL1.4025 mL7.0126 mL
50 mM0.0561 mL0.2805 mL0.5610 mL2.8050 mL
100 mM0.0281 mL0.1403 mL0.2805 mL1.4025 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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2 Enter the in vivo formulation:
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