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Eleclazine hydrochloride

Eleclazine hydrochloride
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Purity:98.95%
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Eleclazine hydrochloride

Catalog No. T15207Cas No. 1448754-43-5
Eleclazine hydrochloride (GS 6615 hydrochloride) is a novel inhibitor of late Na+ current (IC50: 0.7 uM).
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Pack SizePriceAvailabilityQuantity
1 mg$93In Stock
5 mg$197In Stock
10 mg$297In Stock
25 mg$518In Stock
50 mg$745In Stock
100 mg$987In Stock
1 mL x 10 mM (in DMSO)$217In Stock
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Product Introduction

Bioactivity
Description
Eleclazine hydrochloride (GS 6615 hydrochloride) is a novel inhibitor of late Na+ current (IC50: 0.7 uM).
Targets&IC50
Na+ current:0.7 uM
In vitro
Inhibition by GS-6615 of ATX-II enhanced late INa is potently correlated with shortening of myocyte APD and isolated heart MAPD[1]. Eleclazine hydrochloride inhibits ATX-II enhanced late INa in ventricular myocytes, shorten the ATX-II induced prolongation of APD, MAPD, QT interval. It also decreased spatiotemporal dispersion of repolarization and ventricular arrhythmias. Selective inhibition of cardiac late INa with eleclazine hydrochloride confers dual protection against vulnerability to ischemia-induced AF. That decreases atrial and ventricular repolarization abnormalities before and during adrenergic stimulation without negative inotropic effects. [2]
AliasGS 6615 hydrochloride
Chemical Properties
Molecular Weight451.83
FormulaC21H17ClF3N3O3
Cas No.1448754-43-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 100 mg/mL (221.32 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2132 mL11.0661 mL22.1322 mL110.6611 mL
5 mM0.4426 mL2.2132 mL4.4264 mL22.1322 mL
10 mM0.2213 mL1.1066 mL2.2132 mL11.0661 mL
20 mM0.1107 mL0.5533 mL1.1066 mL5.5331 mL
50 mM0.0443 mL0.2213 mL0.4426 mL2.2132 mL
100 mM0.0221 mL0.1107 mL0.2213 mL1.1066 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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