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Fexinidazole

🥰Excellent
Catalog No. T2112Cas No. 59729-37-2
Alias HOE 239

Fexinidazole (HOE 239) is an antiparasitic agent with activity against Trypanosoma cruzi, Tritrichomonas foetus, Trichomonas vaginalis, Entamoeba histolytica, Trypanosoma brucei, and Leishmania donovani. The biologically relevant active metabolites in vivo are the sulfoxide and sulfone.

Fexinidazole

Fexinidazole

🥰Excellent
Purity: 100%
Catalog No. T2112Alias HOE 239Cas No. 59729-37-2
Fexinidazole (HOE 239) is an antiparasitic agent with activity against Trypanosoma cruzi, Tritrichomonas foetus, Trichomonas vaginalis, Entamoeba histolytica, Trypanosoma brucei, and Leishmania donovani. The biologically relevant active metabolites in vivo are the sulfoxide and sulfone.
Pack SizePriceAvailabilityQuantity
5 mg$68In Stock
10 mg$109In Stock
25 mg$198In Stock
50 mg$328In Stock
100 mg$497In Stock
200 mg$693In Stock
500 mg$1,080In Stock
1 mL x 10 mM (in DMSO)$75In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
Fexinidazole (HOE 239) is an antiparasitic agent with activity against Trypanosoma cruzi, Tritrichomonas foetus, Trichomonas vaginalis, Entamoeba histolytica, Trypanosoma brucei, and Leishmania donovani. The biologically relevant active metabolites in vivo are the sulfoxide and sulfone.
Kinase Assay
Promoter-luciferase reporter assay: A 2,767-bp sequence of human survivin gene promoter is isolated from human genomic DNA by PCR using Pyrobest polymerase and the following primers: 5
AliasHOE 239
Chemical Properties
Molecular Weight279.31
FormulaC12H13N3O3S
Cas No.59729-37-2
SmilesCSc1ccc(OCc2ncc(n2C)[N+]([O-])=O)cc1
Relative Density.1.33g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (179.01 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.5803 mL17.9013 mL35.8025 mL179.0126 mL
5 mM0.7161 mL3.5803 mL7.1605 mL35.8025 mL
10 mM0.3580 mL1.7901 mL3.5803 mL17.9013 mL
20 mM0.1790 mL0.8951 mL1.7901 mL8.9506 mL
50 mM0.0716 mL0.3580 mL0.7161 mL3.5803 mL
100 mM0.0358 mL0.1790 mL0.3580 mL1.7901 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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