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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $33 | In Stock | |
2 mg | $47 | In Stock | |
5 mg | $97 | In Stock | |
10 mg | $163 | In Stock | |
25 mg | $266 | In Stock | |
50 mg | $395 | In Stock | |
100 mg | $588 | In Stock | |
500 mg | $1,260 | In Stock | |
1 mL x 10 mM (in DMSO) | $59 | In Stock |
Description | FG 7142 (LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex. FG 7142 , a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM). |
In vitro | FG-7142 has a high efficacy in modulating GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50 = 137 nM) as compared to the other α subunits.FG-7142 has affinity for those expressing the α subunit, the Ki values are 91 nM; 330 nM; 492 nM and 2.150 μM for α1, α2,α3 and α5 subunits, respectively. |
In vivo | FG-7142, administered via intraperitoneal injection at doses of 15 mg/kg, enhances tyrosine hydroxylase activity and dopamine turnover specifically in the medial prefrontal cortex and ventral tegmentum, without impacting mesolimbic or nigrostriatal regions. At doses between 15-30 mg/kg, it stimulates mesolimbocortical dopaminergic projections, resulting in elevated dopamine levels in the prefrontal cortex and nucleus accumbens in rats. |
Alias | ZK 39106, LSU-65 |
Molecular Weight | 225.25 |
Formula | C13H11N3O |
Cas No. | 78538-74-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 30 mg/mL (133.19 mM) ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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