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JTE-013

Catalog No. T15629Cas No. 383150-41-2

JTE-013 is an effective and specific antagonist of S1P2. JTE-013 suppresses the specific binding of radiolabeled S1P to human and rat S1P2 (IC50s: 17 nM and 22 nM, respectively).

JTE-013

JTE-013

Purity: 97.69%
Catalog No. T15629Cas No. 383150-41-2
JTE-013 is an effective and specific antagonist of S1P2. JTE-013 suppresses the specific binding of radiolabeled S1P to human and rat S1P2 (IC50s: 17 nM and 22 nM, respectively).
Pack SizePriceAvailabilityQuantity
5 mg$70In Stock
10 mg$101In Stock
25 mg$224In Stock
50 mg$336In Stock
1 mL x 10 mM (in DMSO)$79In Stock
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Purity:97.69%
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Product Introduction

Bioactivity
Description
JTE-013 is an effective and specific antagonist of S1P2. JTE-013 suppresses the specific binding of radiolabeled S1P to human and rat S1P2 (IC50s: 17 nM and 22 nM, respectively).
Targets&IC50
S1P2 (rat):22 nM, S1P2 (human):17 nM
In vitro
JTE-013 is a S1P2 antagonist. JTE-013 (50-200 μM;?1-3 days) decreased cell viability.?JTE-013 shows 4.2% inhibition of S1P3 and does not antagonize S1P1 at concentrations up to 10 μM.?JTE-013 (10-1000 nM;?30 mins) reverses S1P-induced Akt inhibition and inhibits S1P-induced ERK activation.
In vivo
JTE-013 (gavage;?30 mg/kg daily for 14 consecutive days) decreases tumor size and tumor weight.?the modification of JTE-013 to produce the AB1 compound improved potency, intravenous pharmacokinetics, cellular activity, and antitumor activity in NB and may have enhanced clinical and experimental applicability.
Chemical Properties
Molecular Weight408.29
FormulaC17H19Cl2N7O
Cas No.383150-41-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 100 mg/mL (244.92 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4492 mL12.2462 mL24.4924 mL122.4620 mL
5 mM0.4898 mL2.4492 mL4.8985 mL24.4924 mL
10 mM0.2449 mL1.2246 mL2.4492 mL12.2462 mL
20 mM0.1225 mL0.6123 mL1.2246 mL6.1231 mL
50 mM0.0490 mL0.2449 mL0.4898 mL2.4492 mL
100 mM0.0245 mL0.1225 mL0.2449 mL1.2246 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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