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Laninamivir (R 125489) is an effective inhibitor of influenza neuraminidase (NA) (IC50s: 0.90 nM, 1.83 nM, and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $34 | In Stock | |
2 mg | $47 | In Stock | |
5 mg | $77 | In Stock | |
10 mg | $122 | In Stock | |
25 mg | $198 | In Stock | |
50 mg | $369 | In Stock | |
100 mg | $531 | In Stock |
Description | Laninamivir (R 125489) is an effective inhibitor of influenza neuraminidase (NA) (IC50s: 0.90 nM, 1.83 nM, and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively). |
Targets&IC50 | N5:0.90 nM (IC50), p09N1:1.83 nM (IC50), p57N2:3.12 nM (IC50) |
In vitro | Laninamivir is effective against p57N2, p09N1, and N5 with a similar binding mode to Zanamivir. Laninamivir inhibits efficiently common oseltamivir-resistant viruses, including those with the ubiquitous His274Tyr substitution [1]. |
Alias | R 125489 |
Molecular Weight | 346.34 |
Formula | C13H22N4O7 |
Cas No. | 203120-17-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: Insoluble H2O: 10 mM | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
H2O
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