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m-Chlorophenylbiguanide hydrochloride
🥰Excellent
Catalog No. T22959Cas No. 2113-05-5
Alias 1-(3-Chlorophenyl)biguanidehydrochloride
m-Chlorophenylbiguanide hydrochloride is a 5-HT3 receptor agonist. m-Chlorophenylbiguanide hydrochloride selectively binds 5-HT3(Ki: 0.002 µM) over 5-HT1A(Ki: 10 µM) and 5-HT2(Ki: 10 µM) receptors but also binds to high and low affinity sites on the dopamine transporter(DAT; IC50s: 0.4 and 34.8 µM, respectively, in rat caudate putamen synaptosomal membranes).
m-Chlorophenylbiguanide hydrochloride
🥰Excellent
Purity: 99.87%
Catalog No. T22959Alias 1-(3-Chlorophenyl)biguanidehydrochlorideCas No. 2113-05-5
m-Chlorophenylbiguanide hydrochloride is a 5-HT3 receptor agonist. m-Chlorophenylbiguanide hydrochloride selectively binds 5-HT3(Ki: 0.002 µM) over 5-HT1A(Ki: 10 µM) and 5-HT2(Ki: 10 µM) receptors but also binds to high and low affinity sites on the dopamine transporter(DAT; IC50s: 0.4 and 34.8 µM, respectively, in rat caudate putamen synaptosomal membranes).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 200 mg | $35 | In Stock | |
| 500 mg | $55 | In Stock | |
| 1 g | $78 | In Stock |
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CitedSelect Batch
Purity:99.87%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | 5-HT3 receptor agonist |
| Targets&IC50 | 5-HT3:0.002 µM(Ki), 5-HT2:10 µM(Ki), 5-HT1:10 µM(Ki) |
| In vivo | m-Chlorophenylbiguanide hydrochloride induces depolarization of isolated rat vagus nerve and stimulates inositol phosphate formation in rat frontocingulate cortical slices (EC50s = 0.05 and 4.2 μM, respectively).m-Chlorophenylbiguanide hydrochloride induces bradycardia, an effect that can be reversed by the 5-HT3 receptor antagonist ondansetron, in anaesthetized cats (ED50 = 20.3 nmol/kg)[1]. |
| Alias | 1-(3-Chlorophenyl)biguanidehydrochloride |
| Molecular Weight | 248.11 |
| Formula | C8H11Cl2N5 |
| Cas No. | 2113-05-5 |
| Smiles | Cl.NC(N)=NC(=N)NC1=CC(Cl)=CC=C1 |
| Relative Density. | 1.49g/cm3 |
Storage & Solubility Information
| Storage | store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/mL (241.83 mM)  H2O: < 20 mg/mL (80.61 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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