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NGP555 is a modulator of γ-secretase.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $71 | In Stock | |
2 mg | $101 | In Stock | |
5 mg | $197 | In Stock | |
10 mg | $308 | In Stock | |
25 mg | $519 | In Stock | |
50 mg | $753 | In Stock | |
100 mg | $1,060 | In Stock | |
1 mL x 10 mM (in DMSO) | $215 | In Stock |
Description | NGP555 is a modulator of γ-secretase. |
In vitro | NGP555 effectively lowers Aβ42 in cell cultures (9 nM) and increasing shorter forms of Aβ at the same time . |
In vivo | NGP555 also shows good oral bioavailability and is brain-penetrant with a brain: plasma ratio of ~0.93 in mice. NGP555-treated Tg mice show significant protection from a decline in performance with >65% less decline (P<0.005) when comparing the differential of Tg to non-Tg vehicle-treated mice. NGP555 obviously lowers Aβ42 in the cerebrospinal fluid (CSF) at time points from 8 to10 hours post-dose. When combining the reduction of Aβ42 with an increase in Aβ38, NGP555 is effective at raising CSF Aβ38/42 ratio at 1.87 mg/kg and above . |
Molecular Weight | 406.52 |
Formula | C23H23FN4S |
Cas No. | 1304630-27-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 25 mg/mL (61.50 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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