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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $60 | In Stock | |
2 mg | $85 | In Stock | |
5 mg | $128 | In Stock | |
10 mg | $178 | In Stock | |
25 mg | $396 | In Stock | |
50 mg | $592 | In Stock | |
100 mg | $845 | In Stock | |
1 mL x 10 mM (in DMSO) | $143 | In Stock |
Description | ONO-8590580 (CS-2894) is a negative allosteric modulator of GABAA α5. |
In vivo | The study investigates the effects of ONO-8590580 on MK-801/scopolamine-induced cognitive deficits using the 8-arm radial maze test, with doses of MK-801 and scopolamine at 0.075 mg/kg (i.p.) and 0.2 mg/kg (i.p.), respectively. ONO-8590580 (20 mg/kg, p.o.) significantly reduces errors and total latency compared to the control. Unlike donepezil, ONO-8590580 significantly decreases the number of errors, suggesting it may be more effective for treating AD patients. The data indicate that ONO-8590580 is a novel GABAA α5 NAM that enhances hippocampal memory function without causing anxiogenic or proconvulsant effects. |
Alias | CS-2894 |
Molecular Weight | 376.43 |
Formula | C21H21FN6 |
Cas No. | 1802661-73-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 60 mg/mL (159.39 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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