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ONO-8590580
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Purity:99.54%
ONO-8590580
Catalog No. TQ0040Cas No. 1802661-73-9
ONO-8590580 (CS-2894) is a negative allosteric modulator of GABAA α5.
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $60 | In Stock | |
| 2 mg | $85 | In Stock | |
| 5 mg | $128 | In Stock | |
| 10 mg | $178 | In Stock | |
| 25 mg | $396 | In Stock | |
| 50 mg | $592 | In Stock | |
| 100 mg | $845 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $143 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | ONO-8590580 (CS-2894) is a negative allosteric modulator of GABAA α5. |
| In vivo | The study investigates the effects of ONO-8590580 on MK-801/scopolamine-induced cognitive deficits using the 8-arm radial maze test, with doses of MK-801 and scopolamine at 0.075 mg/kg (i.p.) and 0.2 mg/kg (i.p.), respectively. ONO-8590580 (20 mg/kg, p.o.) significantly reduces errors and total latency compared to the control. Unlike donepezil, ONO-8590580 significantly decreases the number of errors, suggesting it may be more effective for treating AD patients. The data indicate that ONO-8590580 is a novel GABAA α5 NAM that enhances hippocampal memory function without causing anxiogenic or proconvulsant effects. |
| Alias | CS-2894 |
| Molecular Weight | 376.43 |
| Formula | C21H21FN6 |
| Cas No. | 1802661-73-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/mL (159.39 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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