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Repinotan
Catalog No. T61934Cas No. 144980-29-0
Alias BAY x 3702 free base
Repinotan (BAY x 3702 free base) is an orally active, selective 5-HT1A receptor agonist that crosses the blood-brain barrier (BBB), exhibits neuroprotective activity, counteracts morphine-induced depression of ventilation in anesthetized rats, and may be used in studies of acute ischemic stroke and traumatic brain injury.
Repinotan
Catalog No. T61934Alias BAY x 3702 free baseCas No. 144980-29-0
Repinotan (BAY x 3702 free base) is an orally active, selective 5-HT1A receptor agonist that crosses the blood-brain barrier (BBB), exhibits neuroprotective activity, counteracts morphine-induced depression of ventilation in anesthetized rats, and may be used in studies of acute ischemic stroke and traumatic brain injury.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $293 | In Stock | |
| 5 mg | $722 | In Stock | |
| 10 mg | $987 | In Stock | |
| 25 mg | $1,520 | In Stock | |
| 50 mg | $1,980 | In Stock |
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T449434233-69-7
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Purity:99%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Repinotan (BAY x 3702 free base) is an orally active, selective 5-HT1A receptor agonist that crosses the blood-brain barrier (BBB), exhibits neuroprotective activity, counteracts morphine-induced depression of ventilation in anesthetized rats, and may be used in studies of acute ischemic stroke and traumatic brain injury. |
| Targets&IC50 | 5-HT7 Receptor:6 nM (Ki), 5-HT1A Receptor:0.19 nM (Ki, calf hippocampus), 5-HT1A Receptor:0.25 nM (Ki, rat and human cortex), 5-HT1A Receptor:0.59 nM (Ki, rat hippocampus) |
| In vitro | Repinotan affects the anti-apoptotic protein Bcl-2, serotoninergic neurotransmitter glial growth factor S-100beta, nerve growth factor, and inhibits caspase-3 activity via MAPK and PKCα pathways [1]. |
| In vivo | Repinotan (1-100 μg/kg) induces a strong, dose-dependent reduction in infarct size in permanent and transient middle cerebral artery occlusion, as well as in traumatic brain injury paradigms[1]. |
| Alias | BAY x 3702 free base |
| Molecular Weight | 400.49 |
| Formula | C21H24N2O4S |
| Cas No. | 144980-29-0 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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