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Rosuvastatin calcium
🥰Excellent
Catalog No. T1510Cas No. 147098-20-2
Alias ZD 4522 Calcium, Rosuvastatin hemicalcium
Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activity.
Rosuvastatin calcium
🥰Excellent
Purity: 99.68%
Catalog No. T1510Alias ZD 4522 Calcium, Rosuvastatin hemicalciumCas No. 147098-20-2
Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $35 | In Stock | |
| 50 mg | $47 | In Stock | |
| 100 mg | $84 | In Stock | |
| 500 mg | $216 | In Stock |
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Purity:99.68%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activity. |
| Targets&IC50 | HMG-CoA:11 nM |
| In vitro | In streptozotocin-induced diabetic rats, daily administration of Rosuvastatin (20 mg/kg) significantly reduces the content of very low-density lipoprotein (VLDL) within the body. Similarly, in male beagles with normal cholesterol levels, Rosuvastatin (3 mg/kg) effectively lowers the concentration of cholesterol in the plasma. |
| In vivo | In isolated rat hepatocytes (IC50=1.12 nM), Rosuvastatin acts as a high-affinity substrate for OATP-C, inhibiting cholesterol synthesis. Additionally, in endothelial cells, Rosuvastatin suppresses the expression and protein levels of ICAM-1, MCP-1, IL-8, IL-6, and COX-2 mRNA by inhibiting the c-Jun N-terminal kinase and nuclear factor-kB. |
| Alias | ZD 4522 Calcium, Rosuvastatin hemicalcium |
| Molecular Weight | 1001.14 |
| Formula | 2(C22H27FN3O6S)Ca |
| Cas No. | 147098-20-2 |
| Smiles | [Ca++].CC(C)C1=C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)C(=NC(=N1)N(C)S(C)(=O)=O)C1=CC=C(F)C=C1.CC(C)C1=C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)C(=NC(=N1)N(C)S(C)(=O)=O)C1=CC=C(F)C=C1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (199.77 mM), Heating is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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