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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $34 | In Stock | |
50 mg | $47 | In Stock | |
100 mg | $84 | In Stock | |
200 mg | $129 | In Stock | |
500 mg | $216 | In Stock | |
1 mL x 10 mM (in DMSO) | $29 | In Stock |
Description | Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activity. |
In vitro | In streptozotocin-induced diabetic rats, daily administration of Rosuvastatin (20 mg/kg) significantly reduces the content of very low-density lipoprotein (VLDL) within the body. Similarly, in male beagles with normal cholesterol levels, Rosuvastatin (3 mg/kg) effectively lowers the concentration of cholesterol in the plasma. |
In vivo | In isolated rat hepatocytes (IC50=1.12 nM), Rosuvastatin acts as a high-affinity substrate for OATP-C, inhibiting cholesterol synthesis. Additionally, in endothelial cells, Rosuvastatin suppresses the expression and protein levels of ICAM-1, MCP-1, IL-8, IL-6, and COX-2 mRNA by inhibiting the c-Jun N-terminal kinase and nuclear factor-kB. |
Alias | ZD 4522 Calcium, ZD4522, Rosuvastatin hemicalcium |
Molecular Weight | 1001.14 |
Formula | 2(C22H27FN3O6S)Ca |
Cas No. | 147098-20-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (199.77 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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