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Spironolactone
🥰Excellent
Catalog No. T0476Cas No. 52-01-7
Alias SC9420, Abbolactone
Spironolactone (SC9420) is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist.
Spironolactone
🥰Excellent
Purity: 99.63%
Catalog No. T0476Alias SC9420, AbbolactoneCas No. 52-01-7
Spironolactone (SC9420) is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 mg | 31 € | In Stock | |
| 1 mL x 10 mM (in DMSO) | 47 € | In Stock |
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Purity:99.63%
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.Product Introduction
Bioactivity
Chemical Properties
| Description | Spironolactone (SC9420) is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist. |
| Targets&IC50 | Androgen receptor:77 nM |
| In vitro | Spironolactone inhibits the specific binding of stanozololone in the nucleus and prostate cytoplasm of the rat prostate.Spironolactone is a strong AR antagonist with an IC50 of 77 nM, a weak GR antagonist with an IC50 of 2.4 μM, and a weak PR agonist with an EC50 of 740 nM. |
| In vivo | Spironolactone inhibits the specific binding of stanozololone in the nucleus and prostate cytoplasm of the rat prostate.Spironolactone is a strong AR antagonist with an IC50 of 77 nM, a weak GR antagonist with an IC50 of 2.4 μM, and a weak PR agonist with an EC50 of 740 nM. |
| Alias | SC9420, Abbolactone |
| Molecular Weight | 416.57 |
| Formula | C24H32O4S |
| Cas No. | 52-01-7 |
| Smiles | CC(=O)SC1CC2=CC(=O)CCC2(C)C2CCC3(C)C(CCC33CCC(=O)O3)C12 |
| Relative Density. | 1.24g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 20.8 mg/mL (50 mM) DMSO: 45 mg/mL (108.03 mM)  | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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