spironolactone

Spironolactone (SC9420) is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist.

Spironolactone-d3 is a deuterated compound of Spironolactone. Spironolactone has a CAS number of 52-01-7. Spironolactone is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist.

Drospirenone (ZK 3059) is a synthetic spironolactone analogue and progestin with progestational and anti-mineralocorticoid activity.

Mespirenone is a spironolactone derivative and aldosterone antagonist with diuretic effects.

7α-Thiomethylspironolactone is a major metabolite of the synthetic steroid spironolactone.1,2 1.Jankowski, A., Skorek-Jankowska, A., and Lamparczyk, H.Simultaneous determination of spironolactone and its metabolites in human plasmaJ. Pharm. Biomed. Anal.14(8-10)1359-1365(1996) 2.Gardiner, P., Schrode, K., Quinlan, D., et al.Spironolactone metabolism: Steady-state serum levels of the sulfur-containing metabolitesJ. Clin. Pharmacol.29(4)342-347(1989)

7α-Thio Spironolactone is a Spironolactone (sc-204294) metabolite.

Spirorenone is an androstadienone derivative as a highly effective aldosterone antagonist. Spirorenone is 8.6 times as potent as spironolactone, but showed a lower affinity for the mineralocorticoid receptors. In phase I clinical trials Spirorenone was absorbed with a half-life of 20-30 min, achieving maximum concentrations of about 100 ng/ml (10 mg) and 260 ng/ml (40 mg) after 1-2 h. Disposition of the parent drug was biphasic with half-lives of 50-60 min (distribution) and 5-6 h (elimination). Neither significant accumulation nor enzyme induction was observed after prolonged treatment.