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Talipexole dihydrochloride
🥰Excellent
Catalog No. T14490Cas No. 36085-73-1
Alias Domnin, B-HT 920 dihydrochloride
Talipexole dihydrochloride (Domnin) is a dopamine D2 receptor agonist, α2-adrenoceptor agonist, and 5-HT3 receptor antagonist in both rat cortical and intestinal membrane fractions with Ki values of 0.35 μM and 0.22 μM, respectively. It displays antiParkinsonian activity.
Talipexole dihydrochloride
🥰Excellent
Purity: 98.64%
Catalog No. T14490Alias Domnin, B-HT 920 dihydrochlorideCas No. 36085-73-1
Talipexole dihydrochloride (Domnin) is a dopamine D2 receptor agonist, α2-adrenoceptor agonist, and 5-HT3 receptor antagonist in both rat cortical and intestinal membrane fractions with Ki values of 0.35 μM and 0.22 μM, respectively. It displays antiParkinsonian activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $32 | In Stock | |
| 5 mg | $51 | In Stock | |
| 10 mg | $82 | In Stock | |
| 25 mg | $156 | In Stock | |
| 50 mg | $278 | In Stock | |
| 100 mg | $447 | In Stock | |
| 200 mg | $646 | In Stock | |
| 500 mg | $998 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $57 | In Stock |
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5-HT ReceptorAChRAdrenergic ReceptorHistamine ReceptorNorepinephrineSerotonin TransporterSigma receptorSodium ChannelTrk receptor
- $45
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Purity:98.64%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Talipexole dihydrochloride (Domnin) is a dopamine D2 receptor agonist, α2-adrenoceptor agonist, and 5-HT3 receptor antagonist in both rat cortical and intestinal membrane fractions with Ki values of 0.35 μM and 0.22 μM, respectively. It displays antiParkinsonian activity. |
| Targets&IC50 | 5-HT3 receptor:0.22 μM(Ki,rat intestinal membrane), 5-HT3 receptor:0.35 μM(Ki,rat cortical membrane), α2-adrenoceptor (rat):25 nM |
| In vivo | Intracisternal injection of 10 μg/kg Talipexole dihydrochloride promotes vagal-mediated reflex bradycardia induced by injection of angiotensin in β-adrenoceptor-blocked dogs. Intravenous administration of Talipexole dihydrochloride at 30 mcg/kg initially caused an increase in blood pressure in cats. Then there is the long-term drop in blood pressure and heart rate[4]. |
| Alias | Domnin, B-HT 920 dihydrochloride |
| Molecular Weight | 282.23 |
| Formula | C10H17Cl2N3S |
| Cas No. | 36085-73-1 |
| Smiles | Cl.Cl.Nc1nc2CCN(CC=C)CCc2s1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (35.43 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords
Talipexole dihydrochlorideTalipexole DihydrochlorideTalipexoleSerotonin ReceptorInhibitorinhibitDopamineReceptorDopamine ReceptorB-HT-920 DihydrochlorideB-HT920 DihydrochlorideB-HT-920B-HT920B-HT 920 DihydrochlorideB-HT 920Beta ReceptorAdrenergicReceptorAdrenergic Receptor5-hydroxytryptamine Receptor5HTReceptor5-HT Receptor5HT Receptor
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