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Tiagabine hydrochloride
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Tiagabine hydrochloride
Catalog No. T7000Cas No. 145821-59-6
Tiagabine hydrochloride (NO050328 hydrochloride) is the hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. A selective gamma-aminobutyric acid (GABA) reuptake inhibitor.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $50 | In Stock | |
| 25 mg | $63 | In Stock | |
| 50 mg | $113 | In Stock | |
| 100 mg | $203 | In Stock | |
| 200 mg | $331 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $47 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Tiagabine hydrochloride (NO050328 hydrochloride) is the hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. A selective gamma-aminobutyric acid (GABA) reuptake inhibitor. |
| In vitro | Tiagabine is a potent inhibitor of GABA uptake into neurons and glial cells. It is involved in modulating GABA levels, especially in areas such as the hippocampus and thalamus[2]. Tiagabine not only affected the decay kinetics of the IPSCs, it also reduced the frequency of occurrence of both spontaneous and miniature IPSCs[4]. |
| In vivo | Tiagabine offers a significant neuroprotection in global ischemia in gerbils when given 30 min before ischemia but not when given 3 h after ischemia[3]. |
| Alias | NO328 hydrochloride, NO050328 hydrochloride, TGB hydrochloride, Gabitril, Gabitril hydrochloride |
| Molecular Weight | 412.01 |
| Formula | C20H25NO2S2·HCl |
| Cas No. | 145821-59-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 41.2 mg/mL (100 mM) H2O: 20.6 mg/mL (50 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/H2O
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。 Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Dose Conversion
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Keywords
NO050328TGBNO-050328 HydrochlorideNO-050328γ-Aminobutyric acid ReceptorNO 050328NO050328 HydrochlorideTGB HydrochlorideNO 328 HydrochlorideinhibitTiagabine HydrochlorideNO-328 HydrochlorideNO328 HydrochlorideNO-328Gabitril HydrochlorideNO 050328 HydrochlorideGABA ReceptorNO328Gamma-aminobutyric acid ReceptorTiagabineTiagabine hydrochlorideNO 328Inhibitor
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