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Tipepidine hydrochloride is a reversible inhibitor of dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) (IC50: 7.0 μM), with antidepressant-like effect.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $33 | In Stock | |
5 mg | $52 | In Stock | |
10 mg | $77 | In Stock | |
25 mg | $143 | In Stock | |
50 mg | $235 | In Stock | |
100 mg | $355 | In Stock | |
1 mL x 10 mM (in DMSO) | $58 | In Stock |
Description | Tipepidine hydrochloride is a reversible inhibitor of dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) (IC50: 7.0 μM), with antidepressant-like effect. |
Targets&IC50 | D2:7.0 μM |
In vivo | In ACTH-treated rats, Tipepidine (i.p.; 10-40 mg/kg; 0.5-23 hours) significantly decreases the immobility time in the forced swimming test. In ACTH-treated rats, Tipepidine (i.p.; 40 mg/kg) increases the extracellular dopamine level of the nucleus accumbens (NAc) [2]. |
Molecular Weight | 311.89 |
Formula | C15H18ClNS2 |
Cas No. | 1449686-84-3 |
Smiles | Cl.CN1CCCC(C1)=C(c1cccs1)c1cccs1 |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 50 mg/mL (160 mM) DMSO: 41.67 mg/mL (133.60 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
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