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Tipepidine hydrochloride

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Catalog No. T13164Cas No. 1449686-84-3

Tipepidine hydrochloride is a reversible inhibitor of dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) (IC50: 7.0 μM), with antidepressant-like effect.

Tipepidine hydrochloride

Tipepidine hydrochloride

🥰Excellent
Purity: 100.00%
Catalog No. T13164Cas No. 1449686-84-3
Tipepidine hydrochloride is a reversible inhibitor of dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) (IC50: 7.0 μM), with antidepressant-like effect.
Pack SizePriceAvailabilityQuantity
2 mg$33In Stock
5 mg$52In Stock
10 mg$77In Stock
25 mg$143In Stock
50 mg$235In Stock
100 mg$355In Stock
1 mL x 10 mM (in DMSO)$58In Stock
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Purity:100.00%
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Product Introduction

Bioactivity
Description
Tipepidine hydrochloride is a reversible inhibitor of dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) (IC50: 7.0 μM), with antidepressant-like effect.
Targets&IC50
D2:7.0 μM
In vivo
In ACTH-treated rats, Tipepidine (i.p.; 10-40 mg/kg; 0.5-23 hours) significantly decreases the immobility time in the forced swimming test. In ACTH-treated rats, Tipepidine (i.p.; 40 mg/kg) increases the extracellular dopamine level of the nucleus accumbens (NAc) [2].
Chemical Properties
Molecular Weight311.89
FormulaC15H18ClNS2
Cas No.1449686-84-3
SmilesCl.CN1CCCC(C1)=C(c1cccs1)c1cccs1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 50 mg/mL (160 mM)
DMSO: 41.67 mg/mL (133.60 mM), Sonication is recommended.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM3.2063 mL16.0313 mL32.0626 mL160.3129 mL
5 mM0.6413 mL3.2063 mL6.4125 mL32.0626 mL
10 mM0.3206 mL1.6031 mL3.2063 mL16.0313 mL
20 mM0.1603 mL0.8016 mL1.6031 mL8.0156 mL
50 mM0.0641 mL0.3206 mL0.6413 mL3.2063 mL
100 mM0.0321 mL0.1603 mL0.3206 mL1.6031 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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