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Traxoprodil
🥰Excellent
Catalog No. TQ0233Cas No. 134234-12-1
Alias CP101606
Traxoprodil (CP101606) is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM).
Traxoprodil
🥰Excellent
Purity: 99.86%
Catalog No. TQ0233Alias CP101606Cas No. 134234-12-1
Traxoprodil (CP101606) is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $47 | In Stock | |
| 10 mg | $64 | In Stock | |
| 25 mg | Inquiry | In Stock | |
| 50 mg | Inquiry | In Stock | |
| 1 mL x 10 mM (in DMSO) | $52 | In Stock |
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Purity:99.86%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Traxoprodil (CP101606) is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM). |
| Targets&IC50 | NMDAR:10 nM |
| In vivo | Traxoprodil exhibits potent activity by effectively blocking haloperidol-induced catalepsy at doses below 1 mg/kg and counteracting NMDA-induced c-fos induction in mice at a 1 mg/kg dosage [1]. Additionally, traxoprodil demonstrates antidepressant properties in the forced swim test at doses of 20 and 40 mg/kg without affecting locomotor activity in animals [2]. Furthermore, at a concentration of 20 nM administered intracerebroventricularly (i.c.v.), traxoprodil prolongs the onset of generalized tonic-clonic seizures triggered by PTZ (70 mg/kg; i.p.). At an oral dose of 60 mg/kg, it not only delays the initiation of clonic and generalized seizures but also reduces the total duration of seizures experienced [3]. |
| Animal Research | The effect of traxoprodil and SPD on PTZ-induced seizures is investigated by injecting the Adult (90-100 days-old) male Wistar rats (250-300 g) with traxoprodil (0.2, 2 or 20 nM/site), SPD (0.02, 0.2 or 2 nM/site), or with vehicle (0.9% NaCl, 1 μL) 15 min before the administration of PTZ (35 or 70 mg/kg, i.p.) [3]. The Forced swim test is done on male Albino Swiss mice (25-30 g). Traxoprodil (5, 10, 20, 40 mg/kg), imipramine and saline are administered i.p. 60 min before the test. The antidepressant activity is measured [2]. |
| Alias | CP101606 |
| Molecular Weight | 327.42 |
| Formula | C20H25NO3 |
| Cas No. | 134234-12-1 |
| Smiles | OC1(CCN([C@H]([C@@H](O)C2=CC=C(O)C=C2)C)CC1)C3=CC=CC=C3 |
| Relative Density. | 1.228g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: < 0.1 mg/mL (insoluble) DMSO: 62.5 mg/mL (190.89 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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