Shopping Cart

Remove All

Your shopping cart is currently empty

VU0152100

Select Batch

Purity:99.43%

Resource Download

COA LCMS HNMR

VU0152100

Catalog No. T17238Cas No. 409351-28-6

VU0152100 is an effective and selective allosteric potentiator of M4 mAChR (EC50: 380 ± 93 nM).

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$34	In Stock
2 mg	$48	In Stock
5 mg	$81	In Stock
10 mg	$121	In Stock
25 mg	$267	In Stock
50 mg	$519	In Stock
100 mg	$779	In Stock
200 mg	$1,090	In Stock
500 mg	$1,650	In Stock
1 mL x 10 mM (in DMSO)	$100	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "VU0152100"

Product Introduction

Bioactivity

Description	VU0152100 is an effective and selective allosteric potentiator of M4 mAChR (EC50: 380 ± 93 nM).
In vitro	VU0152100 was selective for M4 relative to M1, M2, M3, and M5. VU0152100 dose-dependently potentiated the response to an EC20 concentration of ACh (EC50: 1.9 ± 0.2 μM) and increased the maximal response to ACh to approximately 130%. VU0152100 (10 μM) also increased the potency of ACh to induce GIRK-mediated thallium flux, as manifest by a robust (≈30-fold) leftward shift in the ACh CRC from 77 ± 1.2 nM (veh) to 2.35 ± 0.5 nM [1].
In vivo	Systemic administration of VU0152099 and VU0152100 provides robust brain levels of these compounds, the effects of VU0152099 and VU0152100 were evaluated in reversing amphetamine-induced hyperlocomotion in rats using a dose of 56.6 mg/kg i.p. for each compound with a 30-min pretreatment interval [1].
Alias	VU152100

Chemical Properties

Molecular Weight	341.43
Formula	C18H19N3O2S
Cas No.	409351-28-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 55 mg/mL (161.09 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9289 mL	14.6443 mL	29.2886 mL	146.4429 mL
5 mM	0.5858 mL	2.9289 mL	5.8577 mL	29.2886 mL
10 mM	0.2929 mL	1.4644 mL	2.9289 mL	14.6443 mL
20 mM	0.1464 mL	0.7322 mL	1.4644 mL	7.3221 mL
50 mM	0.0586 mL	0.2929 mL	0.5858 mL	2.9289 mL
100 mM	0.0293 mL	0.1464 mL	0.2929 mL	1.4644 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc