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VU0152100

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Catalog No. T17238Cas No. 409351-28-6
Alias VU152100

VU0152100 is an effective and selective allosteric potentiator of M4 mAChR (EC50: 380 ± 93 nM).

VU0152100

VU0152100

🥰Excellent
Purity: 99.56%
Catalog No. T17238Alias VU152100Cas No. 409351-28-6
VU0152100 is an effective and selective allosteric potentiator of M4 mAChR (EC50: 380 ± 93 nM).
Pack SizePriceAvailabilityQuantity
1 mg$34In Stock
2 mg$48In Stock
5 mg$81In Stock
10 mg$121In Stock
25 mg$267In Stock
50 mg$519In Stock
100 mg$779In Stock
200 mg$1,090In Stock
500 mg$1,650In Stock
1 mL x 10 mM (in DMSO)$100In Stock
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Purity:99.56%
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Product Introduction

Bioactivity
Description
VU0152100 is an effective and selective allosteric potentiator of M4 mAChR (EC50: 380 ± 93 nM).
In vitro
VU0152100 was selective for M4 relative to M1, M2, M3, and M5. VU0152100 dose-dependently potentiated the response to an EC20 concentration of ACh (EC50: 1.9 ± 0.2 μM) and increased the maximal response to ACh to approximately 130%. VU0152100 (10 μM) also increased the potency of ACh to induce GIRK-mediated thallium flux, as manifest by a robust (≈30-fold) leftward shift in the ACh CRC from 77 ± 1.2 nM (veh) to 2.35 ± 0.5 nM [1].
In vivo
Systemic administration of VU0152099 and VU0152100 provides robust brain levels of these compounds, the effects of VU0152099 and VU0152100 were evaluated in reversing amphetamine-induced hyperlocomotion in rats using a dose of 56.6 mg/kg i.p. for each compound with a 30-min pretreatment interval [1].
AliasVU152100
Chemical Properties
Molecular Weight341.43
FormulaC18H19N3O2S
Cas No.409351-28-6
SmilesCOc1ccc(CNC(=O)c2sc3nc(C)cc(C)c3c2N)cc1
Relative Density.1.282 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 55 mg/mL (161.09 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9289 mL14.6443 mL29.2886 mL146.4429 mL
5 mM0.5858 mL2.9289 mL5.8577 mL29.2886 mL
10 mM0.2929 mL1.4644 mL2.9289 mL14.6443 mL
20 mM0.1464 mL0.7322 mL1.4644 mL7.3221 mL
50 mM0.0586 mL0.2929 mL0.5858 mL2.9289 mL
100 mM0.0293 mL0.1464 mL0.2929 mL1.4644 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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