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2-Deoxy-D-glucose

Catalog No. T6742   CAS 154-17-6
Synonyms: 2-Deoxy-D-arabino-hexose, 2-deoxyglucose, D-Arabino-2-deoxyhexose, Ba 2758, NSC 15193, 2-DG

2-Deoxy-D-glucose (2-DG) is an analog of glucose, an inhibitor of glycolysis. 2-Deoxy-D-glucose has antiviral activity, as well as inhibitory cell proliferation and apoptosis-inducing activity.

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2-Deoxy-D-glucose Chemical Structure
2-Deoxy-D-glucose, CAS 154-17-6
Pack Size Availability Price/USD Quantity
250 mg In stock $ 31.00
500 mg In stock $ 42.00
1 g In stock $ 50.00
1 mL * 10 mM (in DMSO) In stock $ 48.00
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Purity: 99.77%
Purity: 99.75%
Purity: 99.31%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 2-Deoxy-D-glucose (2-DG) is an analog of glucose, an inhibitor of glycolysis. 2-Deoxy-D-glucose has antiviral activity, as well as inhibitory cell proliferation and apoptosis-inducing activity.
In vitro METHODS: Pancreatic cancer cells MIA PaCa2, BxPC-3, ASPC-1 and ovarian cancer cells OVCAR-3, HEY, SK-OV-3 were treated with 2-Deoxy-D-glucose (0.01-100 mM) for 48 h. Cell proliferation was detected using MTT.
RESULTS: 2-Deoxy-D-glucose showed significant antiproliferative activity against tumor cells with IC50 values ranging from 1.45-13.34 mM. [1]
METHODS: Triple-negative breast cancer cells Hs578T were treated with 2-Deoxy-D-glucose (15 mM) for 24 days, and cell motility was detected by Migration assay and Invasion assay.
RESULTS: 2-Deoxy-D-glucose inhibited the migration and invasion of Hs578T cells. [2]
In vivo METHODS: To study the effects on leukocyte subpopulation distribution and function, 2-Deoxy-D-glucose (500-1500 mg/kg) was injected intraperitoneally into BDF1 mice once or thrice.
RESULTS: Blood glucose concentrations increased in a dose-dependent manner in mice injected with up to 1500 mg/kg of 2-Deoxy-D-glucose. Corticosterone levels, leukocyte counts in the spleen, and CD3+ cells in the thymus increased after one or three injections of 2-Deoxy-D-glucose up to 1500 mg/kg. 2-Deoxy-D-glucose administration induced dose-dependent changes in thymic and splenic cell distribution and function. [3]
METHODS: To test the antitumor activity in vivo, 2-Deoxy-D-glucose (1000 mg/kg) was administered intraperitoneally to C57BL/6 mice bearing melanoma B16 once daily for eight days.
RESULTS: 2-Deoxy-D-glucose significantly inhibited tumor growth, and TAMs showed a significant decrease in Arg, Fizz, CD206 and Vegf expression after 2-Deoxy-D-glucose treatment. [4]
Cell Research 2×103 H460 or H157 cells are seeded in 96-well cell culture plates. Cells are treated with 5 mM 2-DG only, 5 or 10 μM IGF1R inhibitor II only, or a combination of 2-DG and IGF1R inhibitor II. Cell growth inhibition is determined after 48 h by the CellTiter 96® AQueous nonradioactive cell proliferation assay. (Only for Reference)
Synonyms 2-Deoxy-D-arabino-hexose, 2-deoxyglucose, D-Arabino-2-deoxyhexose, Ba 2758, NSC 15193, 2-DG
Molecular Weight 164.16
Formula C6H12O5
CAS No. 154-17-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 16.4 mg/mL (100 mM)

DMSO: 16.4 mg/mL (100 mM)

TargetMolReferences and Literature

1. Malm SW, et al. The anti-tumor efficacy of 2-deoxyglucose and D-allose are enhanced with p38 inhibition in pancreatic and ovarian cell lines. J Exp Clin Cancer Res. 2015 Apr 1;34(1):31. 2. O'Neill S, et al. 2-Deoxy-D-Glucose inhibits aggressive triple-negative breast cancer cells by targeting glycolysis and the cancer stem cell phenotype. Sci Rep. 2019 Mar 7;9(1):3788. 3. Dréau D, et al. Effects of 2-deoxy-D-glucose administration on immune parameters in mice. Immunopharmacology. 1998 Jun;39(3):201-13. 4. Zhao Q, et al. 2-Deoxy-d-Glucose Treatment Decreases Anti-inflammatory M2 Macrophage Polarization in Mice with Tumor and Allergic Airway Inflammation. Front Immunol. 2017 Jun 1;8:637. 5. Huang CC, et al. Dis Model Mech. 2015, 8(10):1247-54.

TargetMolCitations

1. Yuhan C, Lu J, Xu Y, et al. The chemical reprogramming of unipotent adult germ cells towards authentic pluripotency and de novo establishment of imprinting. Protein & Cell. 2022 2. Ma W, Wu Q, Wang S, et al.A breakdown of metabolic reprogramming in microglia induced by CKLF1 exacerbates immune tolerance in ischemic stroke.Journal of Neuroinflammation.2023, 20(1): 1-23.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Tobacco Monomer Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Metabolism Compound Library FDA-Approved & Pharmacopeia Drug Library Human Endogenous Metabolite Compound Library Plus Bioactive Compound Library Anti-Tumor Natural Product Library Inhibitor Library

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Keywords

2-Deoxy-D-glucose 154-17-6 Apoptosis Metabolism Microbiology/Virology Hexokinase HSV 2-Deoxy-D-arabino-hexose 2-deoxyglucose D-Arabino-2-deoxyhexose Ba 2758 NSC 15193 2 Deoxy D glucose 2-DG Herpes simplex virus inhibit NSC-15193 2DeoxyDglucose Inhibitor NSC15193 inhibitor

 

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