Home Tools

Atazanavir sulfate

Catalog No. T0100 CAS 229975-97-7

Synonyms: BMS-232632, BMS-232632 sulfate

Atazanavir sulfate (BMS-232632 sulfate) is an azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with other ANTI-HIV AGENTS.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Atazanavir sulfate, CAS 229975-97-7

Pack Size	Availability	Price/USD
5 mg	In stock	$ 39.00
10 mg	In stock	$ 63.00
25 mg	In stock	$ 98.00
50 mg	In stock	$ 126.00
100 mg	In stock	$ 216.00
200 mg	In stock	$ 323.00
500 mg	In stock	$ 543.00
1 mL * 10 mM (in DMSO)	In stock	$ 64.00

Bulk Inquiry

Select Batch

Purity: 99.67%

Purity: 99.31%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Atazanavir sulfate (BMS-232632 sulfate) is an azapeptide and HIV-PROTEASE INHIBITOR that is used in the treatment of HIV INFECTIONS and AIDS in combination with other ANTI-HIV AGENTS.
Targets&IC50	HIV protease:2.66 nM(Ki)
In vivo	Atazanavir (30 mM) treatment of LS180V cells resulted in a 2.5-fold increase in the expression of P-gp associated with immune responses and a decrease in intracellular Rh123. In glioblastoma cell lines U251, T98G, and LN229, Atazanavir inhibited cell growth and significantly elevated levels of GRP78 and CHOP proteins. Additionally, Atazanavir inhibited the human 20S proteasome. In U251 glioma cells, Atazanavir exposure led to a marked increase in polyubiquitinated proteins of various sizes. When applied to H9 cells infected with a virus, Atazanavir obstructed the proteolytic cleavage of the viral gag precursor p55 polyprotein, with an IC50 of approximately 47 nM. Atazanavir demonstrated potent antiviral activity against the RF/MT-2 strain, with an EC50 of 3.89 nM. Finally, at 30 μM, Atazanavir altered the magnitude of endoplasmic reticulum stress and the expression of UPR genes in HepG2 cells.
Kinase Assay	Protease assays: To determine the inhibition constants (Ki) for each Prt inhibitor, purified HIV-1 RF wild-type Prt (2.5 nM) is incubated at 37 ℃ with 1 μM to 15 μM fluorogenic substrate in reaction buffer (1 M NaCl, 1 mM EDTA, 0.1 M sodium acetate [pH 5.5], 0.1% polyethylene glycol 8000) in the presence or absence of Atazanavir. Cleavage of the substrate is quantified by measuring an increase in fluorescent emission at 490 nM after excitation at 340 nM using a Cytofluor 4000. Reactions are carried out using 1.36 μM, 1.66 μM, 2.1 μM, 3.0 μM, 5.0 μM, or 15 μM substrate in the presence of five concentrations of Atazanavir (1.25 nM to 25 nM). Substrate cleavage is monitored at 5-min intervals for 30 min. Cleavage rates are then determined for each sample at early time points in the reaction, and Ki values are determined from the slopes of the resulting Michaelis-Menten plots.
Cell Research	To determine cytotoxicity, host cells are incubated in the presence of serially diluted Atazanavir for 6 days and cell viability is quantitated using an XTT[2,3-bis(2-methoxy-4-nitro-5-sulfophenyl-2H-tetrazolium-5-carboxanilide] assay to calculate the 50% cytotoxic concentrations (CC50s). To assess the effect of human serum proteins on antiviral activity, the 10% fetal calf serum normally used for assays is replaced with 40% adult human serum or 1 mg of α1-acid glycoprotein/mL.(Only for Reference)

Synonyms	BMS-232632, BMS-232632 sulfate
Molecular Weight	802.93
Formula	C38H52N6O7·H2SO4
CAS No.	229975-97-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 96 mg/mL (119.6 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Robinson BS, et al. Antimicrob Agents Chemother, 2000, 44(8), 2093-2099. 2. Zhang D, et al. Drug Metab Dispos, 2005, 33(11), 1729-1739. 3. Pyrko P, et al. Cancer Res, 2007, 67(22), 10920-10928. 4. Parker RA, et al. Mol Pharmacol, 2005, 67(6), 1909-1919. 5. Perloff ES, et al. Drug Metab Dispos, 2005, 33(6), 764-770.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Anti-Neurodegenerative Disease Compound Library EMA Approved Drug Library Drug Repurposing Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Inhibitor Library FDA-Approved & Pharmacopeia Drug Library Protease Inhibitor Library

Related Products

Related compounds with same targets

Inz-1 APD668 Pradefovir mesylate PF-4981517 β-Apo-8'-carotenal Zederone Friedelin Ticagrelor

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step Two: Enter the in vivo formulation

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

Calculate Reset

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Calculator

Molarity Calculator

Dilution Calculator

Reconstitution Calculation

Molecular Weight Calculator

Mass

Concentration

Volume

Molecular Weight

Molarity Calculator allows you to calculate the

Mass of a compound required to prepare a solution of known volume and concentration
Volume of solution required to dissolve a compound of known mass to a desired concentration
Concentration of a solution resulting from a known mass of compound in a specific volume

See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

Concentration (Start)

Volume (Start)

Concentration (End)

Volume (End)

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Molecule Formula

Molecular Weight g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Atazanavir sulfate 229975-97-7 Membrane transporter/Ion channel Metabolism Microbiology/Virology Neuroscience Proteases/Proteasome P450 SARS-CoV HIV Protease P-gp BMS-232632 Sulfate CYPs Human immunodeficiency virus BMS-232632 CD243 Inhibitor ABCB1 Atazanavir Sulfate Cytochrome P450 BMS-232632 sulfate BMS232632 Sulfate Multidrug resistance protein 1 BMS232632 BMS 232632 Sulfate Cluster of differentiation 243 SARS coronavirus Atazanavir Pgp HIV BMS 232632 inhibit P-glycoprotein MDR1 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.