Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Azelastine hydrochloride (Astelin) is a phthalazinone derivative with antihistaminergic activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
50 mg | In stock | $ 30.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 45.00 |
Description | Azelastine hydrochloride (Astelin) is a phthalazinone derivative with antihistaminergic activity. |
In vivo | In the rat basophilic leukemia RBL-2H3 cell line, Azelastine inhibited antigen (Ag)-induced TNF-alpha release (IC50=25.7 mM) and ionomycin-induced TNF-alpha release (IC50=1.66 mM). In mouse peritoneal macrophages, Azelastine suppressed inducible nitric oxide synthase (iNOS) mRNA expression and nitric oxide (NO) production. In normal human mast cells, Azelastine inhibited the secretion of IL-6, TNF-alpha, and IL-8, and the activation of NF-κB, as well as intracellular calcium levels. In human gingival fibroblasts, Azelastine dose-dependently inhibited DNA and protein synthesis. |
Synonyms | Optivar, Azelastine HCl, Allergodil, Astelin |
Molecular Weight | 418.36 |
Formula | C22H24ClN3O·HCl |
CAS No. | 79307-93-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 84 mg/mL (200.78 mM)
H2O: 35 mg/mL (83.66 mM)
Ethanol: 57 mg/mL(136.2 mM)
You can also refer to dose conversion for different animals. More
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