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Bexarotene
Catalog No. T6410Cas No. 153559-49-0
Alias Targretin, Ro 26-4455, LGD1069
Bexarotene (LGD1069) is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL).
Bexarotene
Catalog No. T6410Alias Targretin, Ro 26-4455, LGD1069Cas No. 153559-49-0
Bexarotene (LGD1069) is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $30 | In Stock | |
| 25 mg | $44 | In Stock | |
| 50 mg | $62 | In Stock | |
| 100 mg | $91 | In Stock | |
| 200 mg | $123 | In Stock | |
| 500 mg | $261 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $39 | In Stock |
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Purity:99%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Bexarotene (LGD1069) is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL). |
| In vitro | Bexarotene inhibited the expression of retinoid X receptor alpha and retinoic acid receptor alpha proteins in CTCL cell lines (MJ,HUT78 and 11 h).1 mM and 10 mM Bexarotene treatment of CTCL cell lines (MJ,HUT78 and 11 h) for 96 h increased cellular sub-G1 populations and membrane-bound protein V binding in a dose-dependent manner. Bexarotene treatment reduced the levels of surviving proteins, activated caspase-3 and cleaved poly (ADP-ribose) polymerase, but had no significant effect on the expression of Fas/Fas ligand and bcl-2 proteins in all three CTCL lines.Bexarotene induced a loss of viability and a more pronounced inhibition of clone formation in HH and Hut-78 cells proliferation, while the MJ line showed resistance. |
| In vivo | Bexarotene inhibited the expression of retinoid X receptor alpha and retinoic acid receptor alpha proteins in CTCL cell lines (MJ,HUT78 and 11 h).1 mM and 10 mM Bexarotene treatment of CTCL cell lines (MJ,HUT78 and 11 h) for 96 h increased cellular sub-G1 populations and membrane-bound protein V binding in a dose-dependent manner. Bexarotene treatment reduced the levels of surviving proteins, activated caspase-3 and cleaved poly (ADP-ribose) polymerase, but had no significant effect on the expression of Fas/Fas ligand and bcl-2 proteins in all three CTCL lines.Bexarotene induced a loss of viability and a more pronounced inhibition of clone formation in HH and Hut-78 cells proliferation, while the MJ line showed resistance. |
| Kinase Assay | Biacore studies: Competition assays are performed on a Biacore S51. A Series S Sensor chip CM5 is derivatized for immobilization of a PentaHis antibody for capture of the His-tagged p53. The level of capture is ~ 200 response units (1 response unit corresponds to 1 pg of protein per mm 2). The concentration of MDM2 protein is kept constant at 300 nM. Test compounds are dissolved in DMSO at 10 mM and further diluted to make a concentration series of inhibitor in each MDM2 test sample. The assays are run at 25 °C in running buffer (10 mM Hepes, 0.15 M NaCl, 2% DMSO). MDM2-p53 binding in the presence of inhibitor is calculated as a percentage of binding in the absence of inhibitor and IC50 is calculated using Microsoft Excel |
| Alias | Targretin, Ro 26-4455, LGD1069 |
| Molecular Weight | 348.48 |
| Formula | C24H28O2 |
| Cas No. | 153559-49-0 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 20 mg/mL (57.39 mM), Sonication is recommended.  Ethanol: 7 mg/mL (20 mM)), Heating is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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