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C188-9

Catalog No. T4650Cas No. 432001-19-9
Alias TTI-101

C188-9 (TTI-101) is a Stat3 inhibitor with an IC50 of 4-7 μM.

C188-9

C188-9

Purity: 100%
Catalog No. T4650Alias TTI-101Cas No. 432001-19-9
C188-9 (TTI-101) is a Stat3 inhibitor with an IC50 of 4-7 μM.
Pack SizePriceAvailabilityQuantity
1 mg$38In Stock
2 mg$54In Stock
5 mg$89In Stock
10 mg$125In Stock
25 mg$263In Stock
50 mg$418In Stock
100 mg$625In Stock
500 mg$1,330In Stock
1 mL x 10 mM (in DMSO)$97In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
C188-9 (TTI-101) is a Stat3 inhibitor with an IC50 of 4-7 μM.
Targets&IC50
STAT3:4-7 μM
In vitro
For apoptosis studies, AML cell lines and primary samples are treated for 24 hours with C188-9, then apoptotic cells are quantified by FACS analysis for annexin V-labeled cells. The EC50s for apoptosis induction are quite variable, ranging from 6 μM to over 50 μM
In vivo
In an analysis of approximately 13,528 discernible genes, C188 influences the expression of 37 gene transcripts (17 downregulated and 20 upregulated, false discovery rate (fdr)<0.01, fold change≥1.5), including 7 known targets of STAT3. Conversely, C188-9 exhibits a broader impact, modifying the expression of 384 genes related to oncogenesis (95 down- and 289 up-regulated), 76 of which are regulated by STAT3 (38 down-regulated and 38 up-regulated). Notably, C188-9 treatment downregulates 24 out of 38 genes (63%) previously identified as upregulated by STAT3. Furthermore, C188-9 downregulates an additional 10 genes (fdr <0.01, fold change≥1.5) known to be upregulated by STAT1, suggesting that 83.3% (40 out of 48) of the genes downregulated by C188-9 are positively regulated by STAT1. This includes sixteen genes co-regulated by both STAT3 and STAT1. The findings suggest that C188-9's modulation of gene transcript levels in head and neck squamous cell carcinoma (HNSCC) tumors may be attributed to its dual influence on STAT3 and STAT1 pathways.
AliasTTI-101
Chemical Properties
Molecular Weight471.52
FormulaC27H21NO5S
Cas No.432001-19-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 60 mg/mL (127.25 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1208 mL10.6040 mL21.2080 mL106.0400 mL
5 mM0.4242 mL2.1208 mL4.2416 mL21.2080 mL
10 mM0.2121 mL1.0604 mL2.1208 mL10.6040 mL
20 mM0.1060 mL0.5302 mL1.0604 mL5.3020 mL
50 mM0.0424 mL0.2121 mL0.4242 mL2.1208 mL
100 mM0.0212 mL0.1060 mL0.2121 mL1.0604 mL

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